Miniatura

Fitxers

667493.pdf (319.97 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2015-05-01

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/106872

Multiple BRAF Wild-Type Melanomas During Dabrafenib Treatment for Metastatic BRAF-Mutant Melanoma.

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1001/jamadermatol.2014.4115

Resum

IMPORTANCE: BRAF inhibitors have become the standard of care in metastatic BRAF-mutant melanomas. Compared with chemotherapies, BRAF inhibitors improve overall and disease-free survival and speed the recovery of symptomatic patients with metastatic disease. The most worrisome finding is the possible development of resistance to new malignant tumors. OBSERVATIONS: A patient in her 30s developed massive BRAFV600E melanoma metastasis during her 30th week of pregnancy. After emergency cesarean delivery, oral dabrafenib treatment was initiated, and a partial radiologic response was confirmed within 1 month. At dermatologic digital follow-up aided by confocal microscopy 8 weeks after initiation of dabrafenib treatment, 4 melanomas were detected. Unfortunately, within the next month, the melanoma rapidly progressed. The 4 new melanomas were wild-type BRAFmelanomas, whereas the new metastasis carried a different BRAF mutation (S467L). CONCLUSIONS AND RELEVANCE: Cutaneous malignant tumors are the most frequent adverse events of BRAF inhibitors; therefore, strict dermatologic surveillance in a referral center aided by digital follow-up is mandatory, especially when multiple nevi are present and these drugs are used in an adjuvant setting. In view of our findings, the pathogenesis of the development of new melanomas seems to be different from therapy resistance. Whether paradoxical RAF activation could explain these BRAF wild-type secondary malignant tumors is still unknown.

Matèries

Melanoma, Càncer de pell, Metàstasi

Matèries (anglès)

Melanoma, Skin cancer, Metastasis

Citació

Col·leccions

Articles publicats en revistes (Fonaments Clínics)

Citació

CARRERA ÁLVAREZ, Cristina, PUIG BUTILLÉ, Joan anton, TELL MARTÍ, Gemma, GARCÍA HERRERA, Adriana, BADENAS ORQUIN, Celia, ALÓS I HERNÁNDEZ, Llúcia, PUIG I SARDÀ, Susana, MALVEHY, J. (josep). Multiple BRAF Wild-Type Melanomas During Dabrafenib Treatment for Metastatic BRAF-Mutant Melanoma.. _JAMA Dermatology_. 2015. Vol. 151, núm. 5, pàgs. 544-548. [consulta: 27 de gener de 2026]. ISSN: 2168-6068. [Disponible a: https://hdl.handle.net/2445/106872]

Exportar metadades

JSON - METS

Compartir registre