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833108.pdf (3.44 MB)

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2023-05-09

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cc-by (c) Andreu-Fernández, V. et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/213381

Effect of Postnatal Epigallocatechin-Gallate Treatment on Cardiac Function in Mice Prenatally Exposed to Alcohol

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Recurs relacionat

https://doi.org/10.3390/antiox12051067

Resum

Prenatal alcohol exposure affects the cardiovascular health of the offspring. Epigallocatechin-3-gallate (EGCG) may be a protective agent against it, but no data are available regarding its impact on cardiac dysfunction. We investigated the presence of cardiac alterations in mice prenatally exposed to alcohol and the effect of postnatal EGCG treatment on cardiac function and related biochemical pathways. C57BL/6J pregnant mice received 1.5 g/kg/day (Mediterranean pattern), 4.5 g/kg/day (binge pattern) of ethanol, or maltodextrin until Day 19 of pregnancy. Post-delivery, treatment groups received EGCG-supplemented water. At post-natal Day 60, functional echocardiographies were performed. Heart biomarkers of apoptosis, oxidative stress, and cardiac damage were analyzed by Western blot. BNP and Hif1α increased and Nrf2 decreased in mice prenatally exposed to the Mediterranean alcohol pattern. Bcl-2 was downregulated in the binge PAE drinking pattern. Troponin I, glutathione peroxidase, and Bax increased in both ethanol exposure patterns. Prenatal alcohol exposure led to cardiac dysfunction in exposed mice, evidenced by a reduced ejection fraction, left ventricle posterior wall thickness at diastole, and Tei index. EGCG postnatal therapy restored the physiological levels of these biomarkers and improved cardiac dysfunction. These findings suggest that postnatal EGCG treatment attenuates the cardiac damage caused by prenatal alcohol exposure in the offspring.

Matèries

Alcohol, Malalties cardiovasculars, Mares i fills, Alcoholisme en l'embaràs, Estrès oxidatiu, Antioxidants

Matèries (anglès)

Alcohol, Cardiovascular diseases, Mother and child, Alcoholism in pregnancy, Oxidative stress, Antioxidants

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

ANDREU FERNÁNDEZ, Vicente, SERRA DELGADO, Mariona, ALMEIDA TOLEDANO, Laura, GARCÍA MESEGUER, Àgueda, VIEIROS, Melina, RAMOS-TRIGUERO, Anna, MUÑOZ LOZANO, Concha, NAVARRO TAPIA, Elisabet, MARTINEZ, Leopoldo, GARCÍA ALGAR, Óscar, GÓMEZ ROIG, Ma. dolores. Effect of Postnatal Epigallocatechin-Gallate Treatment on Cardiac Function in Mice Prenatally Exposed to Alcohol. _Antioxidants_. 2023. Vol. 12, núm. 5. [consulta: 7 de gener de 2026]. ISSN: 2076-3921. [Disponible a: https://hdl.handle.net/2445/213381]

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