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marques2016_2277.pdf (1.49 MB)

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2016-10-05

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cc by (c) Marques et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/103904

Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery

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http://dx.doi.org/10.1016/j.nano.2016.09.010

Resum

The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.

Matèries

Nanomedicina, Malària

Matèries (anglès)

Nanomedicine, Malaria

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Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))

Citació

MARQUES, Joana, VALLE DELGADO, Juan josé, URBÁN, Patricia, BARÓ, Elisabet, PROHENS LÓPEZ, Rafael, MAYOR APARICIO, Alfredo gabriel, CISTERÓ, Pau, DELVES, Michael, SINDEN, Robert e., GRANDFILS, Christian, PAZ, José l. de, GARCÍA SALCEDO, José a., FERNÀNDEZ BUSQUETS, Xavier. Adaptation of targeted nanocarriers to changing requirements in
                antimalarial drug delivery. _Nanomedicine: Nanotechnology_. Biology. Vol.  and Medicine, núm. 2016. [consulta: 20 de gener de 2026]. ISSN: 1549-9634. [Disponible a: https://hdl.handle.net/2445/103904]

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