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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/118465
Alternative access to functionalized 2,8-ethanonoradamantane derivatives
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7a-(Methoxycarbonyl)-N-methyl-1,3a,5,6,7,7a-hexahydro-4H-1,4,6-(epiethane[1,1,2]triyl) indene-4,9-dicarboximide has been prepared through a modification of a previous synthetic sequence, in which the benzyloxymethyl hydroxyl protecting group has been replaced by methoxymethyl, to avoid the apparent formation of a benzyl ester derivative as a side product. The overall yield of the new synthetic sequence is comparable to the previous one. Two advantages of the new procedure are: (a) no benzyl ester was formed and (b) a stereoisomeric mixture of syn- and anti-alcohols at the beginning of the synthetic sequence could be separated and the rest of the synthesis could be carried out with the main syn-stereoisomer instead of the corresponding stereoisomeric mixture as it was the case in the previous process.
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CAMPS GARCÍA, Pelayo, et al. Alternative access to functionalized 2,8-ethanonoradamantane derivatives. Molecules. 2017. Vol. 22, num. 6, pags. 906. ISSN 1420-3049. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/118465