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646660.pdf (4.32 MB)

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2014-10-31

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cc-by (c) Nait Chabane, Yassine et al., 2014
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/121165

Characterisation of pellicles formed by acinetobacter baumannii at the air-liquidi interface

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Recurs relacionat

https://doi.org/10.1371/journal.pone.0111660

Resum

The clinical importance of Acinetobacter baumannii is partly due to its natural ability to survive in the hospital environment. This persistence may be explained by its capacity to form biofilms and, interestingly, A. baumannii can form pellicles at the air-liquid interface more readily than other less pathogenic Acinetobacter species. Pellicles from twenty-six strains were morphologically classified into three groups: I) egg-shaped (27%); II) ball-shaped (50%); and III) irregular pellicles (23%). One strain representative of each group was further analysed by Brewster's Angle Microscopy to follow pellicle development, demonstrating that their formation did not require anchoring to a solid surface. Total carbohydrate analysis of the matrix showed three main components: Glucose, GlcNAc and Kdo. Dispersin B, an enzyme that hydrolyzes poly-N-acetylglucosamine (PNAG) polysaccharide, inhibited A. baumannii pellicle formation, suggesting that this exopolysaccharide contributes to pellicle formation. Also associated with the pellicle matrix were three subunits of pili assembled by chaperon-usher systems: the major CsuA/B, A1S_1510 (presented 45% of identity with the main pilin F17-A from enterotoxigenic Escherichia coli pili) and A1S_2091. The presence of both PNAG polysaccharide and pili systems in matrix of pellicles might contribute to the virulence of this emerging pathogen.

Matèries

Bacteris patògens, Bacteriologia, Qualitat de l'aire

Matèries (anglès)

Pathogenic bacteria, Bacteriology, Air quality

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Articles publicats en revistes (Fonaments Clínics)

Citació

NAIT CHABANE, Yassine, et al. Characterisation of pellicles formed by acinetobacter baumannii at the air-liquidi interface. PLoS One. 2014. Vol. 9, núm. 10, pàgs. e111660. ISSN 1932-6203. [consulta: 8 de maig de 2026]. Disponible a: https://hdl.handle.net/2445/121165

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