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2023-09-24

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cc-by (c) Solana-Balaguer, J. et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/206806

Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity

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https://doi.org/10.1002/jev2.12355
 https://doi.org/10.1002/jev2.12355

Abstract

Extracellular vesicles (EVs) play an important role in intercellular communication as carriers of signalling molecules such as bioactive miRNAs, proteins and lipids. EVs are key players in the functioning of the central nervous system (CNS) by influencing synaptic events and modulating recipient neurons. However, the specific role of neuron-to-neuron communication via EVs is still not well understood. Here, we provide evidence that primary neurons uptake neuron-derived EVs in the soma, dendrites, and even in the dendritic spines, and carry synaptic proteins. Neuron-derived EVs increased spine density and promoted the phosphorylation of Akt and ribosomal protein S6 (RPS6), via TrkB-signalling, without impairing the neuronal network activity. Strikingly, EVs exerted a trophic effect on challenged nutrient-deprived neurons. Altogether, our results place EVs in the spotlight for synaptic plasticity modulation as well as a possible therapeutic tool to fight neurodegeneration.

Subject

Malalties neurodegeneratives, Neurones, Cèl·lules, Sinapsi, Sistema nerviós central, Comunicació

Subject (English)

Neurodegenerative Diseases, Neurons, Cells, Synapses, Central nervous system, Communication

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Articles publicats en revistes (Física de la Matèria Condensada)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

Citation

SOLANA BALAGUER, Júlia, et al. Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity. Journal Of Extracellular Vesicles. 2023. Vol. 12, num. 9. ISSN 2001-3078. [consulted: 7 of August of 2026]. Available at: https://hdl.handle.net/2445/206806

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