Files
Document type
ArticleVersion
Accepted versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/171522
Anti-inflammatory effects of animal plasma protein supplementation in mice undergoing simultaneous gut and lung inflammation
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
We aimed to determine whether dietary supplementation with spray-dried porcine plasma (SDP) is effective in mice exposed to a dual S. aureus enterotoxin B (SEB) and lipopolysaccharide (LPS) challenges inducing simultaneous inflammation in the gut and lung. Male C57BL/6 mice were fed control or SDP-supplemented diets from weaning for 14 days. At the end of the experimental period, animals received LPS intranasal followed by SEB intraperitoneal doses. The dual challenge increased leukocyte recruitment into mesenteric lymph nodes and lung tissue, the percentage of activated monocytes and neutrophils, as well as the expression of Tnf-α, Ifn-γ and Il-1β in lung tissue and jejunal mucosa, while SDP attenuated these effects. Moreover, SDP augmented the expression of Il-10, Tgf-β and Foxp3 in these tissues. Supplementation with animal plasma proteins attenuated lung and intestinal inflammation provoked by simultaneous administration of LPS and SEB toxins and increased the expression of anti-inflammatory cytokines.
Subject (English)
Citation
Citation
MIRÓ MARTÍ, Ma. Lluïsa, et al. Anti-inflammatory effects of animal plasma protein supplementation in mice undergoing simultaneous gut and lung inflammation. Food and Agricultural Immunology. 2020. Vol. 31, num. 1, pags. 910. ISSN 0954-0105. [consulted: 13 of June of 2026]. Available at: https://hdl.handle.net/2445/171522