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2022-09-30

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cc-by (c) García-Arroyo, Rocío et al., 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/190679

CERKL, a Retinal Dystrophy Gene, Regulates Mitochondrial Transport and Dynamics in Hippocampal Neurons.

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https://doi.org/10.3390/ijms231911593

Abstract

Mutations in the Ceramide Kinase-like (CERKL) gene cause retinal dystrophies, characterized by progressive degeneration of retinal neurons, which eventually lead to vision loss. Among other functions, CERKL is involved in the regulation of autophagy, mitochondrial dynamics, and metabolism in the retina. However, CERKL is nearly ubiquitously expressed, and it has been recently described to play a protective role against brain injury. Here we show that Cerkl is expressed in the hippocampus, and we use mouse hippocampal neurons to explore the impact of either overexpression or depletion of CERKL on mitochondrial trafficking and dynamics along axons. We describe that a pool of CERKL localizes at mitochondria in hippocampal axons. Importantly, the depletion of CERKL in the CerklKD/KO mouse model is associated with changes in the expression of fusion/fission molecular regulators, induces mitochondrial fragmentation, and impairs axonal mitochondrial trafficking. Our findings highlight the role of CERKL, a retinal dystrophy gene, in the regulation of mitochondrial health and homeostasis in central nervous system anatomic structures other than the retina.

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Hipocamp (Cervell), Neurones, Mitocondris

Subject (English)

Hippocampus (Brain), Neurons, Mitochondria

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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GARCÍA-ARROYO, Rocío, MARFANY I NADAL, Gemma and MIRRA, Serena. CERKL, a Retinal Dystrophy Gene, Regulates Mitochondrial Transport and Dynamics in Hippocampal Neurons. International Journal of Molecular Sciences. 2022. Vol. 23, num. 19, pags. 11593. ISSN 1661-6596. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/190679

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