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http://hdl.handle.net/2445/159357
Title: | Motility and morphodynamics of confined cells |
Author: | Lavi, Ido Meunier, Nicolas Voituriez, Raphaël Casademunt i Viader, Jaume |
Keywords: | Cèl·lules Dinàmica molecular Dinàmica de fluids Cells Molecular dynamics Fluid dynamics |
Issue Date: | 6-Feb-2020 |
Publisher: | American Physical Society |
Abstract: | We introduce a minimal hydrodynamic model of polarization, migration, and deformation of a biologicalcell confined between two parallel surfaces. In our model, the cell is driven out of equilibrium by an activecytsokeleton force that acts on the membrane. The cell cytoplasm, described as a viscous droplet in the Darcyflow regime, contains a diffusive solute that actively transduces the applied cytoskeleton force. While fairlysimple and analytically tractable, this quasi-two-dimensional model predicts a range of compelling dynamicbehaviours. A linear stability analysis of the system reveals that solute activity first destabilizes a globalpolarization-translation mode, prompting cell motility through spontaneous symmetry breaking. At higheractivity, the system crosses a series of Hopf bifurcations leading to coupled oscillations of droplet shape andsolute concentration profiles. At the nonlinear level, we find traveling-wave solutions associated with uniquepolarized shapes that resemble experimental observations. Altogether, this model offers an analytical paradigmof active deformable systems in which viscous hydrodynamics are coupled to diffusive force transducers. |
Note: | Reproducció del document publicat a: https://doi.org/10.1103/PhysRevE.101.022404 |
It is part of: | Physical Review E, 2020, vol. 101, num. 2, p. 022404 |
URI: | http://hdl.handle.net/2445/159357 |
Related resource: | https://doi.org/10.1103/PhysRevE.101.022404 |
ISSN: | 1539-3755 |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
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