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Title: Viability-reducing activity of Coryllus avellana L. extracts against human cancer cell lines
Author: Gallego, Ana
Metón Teijeiro, Isidoro
Baanante, Isabel V.
Ouazzani , Jamal
Adelin, Amelie
Palazón Barandela, Javier
Bonfill Baldrich, Ma. Mercedes
Moyano Claramunt, Elisabet
Keywords: Farmacologia
Cèl·lules canceroses
Cromatografia de líquids d'alta resolució
Cancer cells
High performance liquid chromatography
Issue Date: 1-Mar-2017
Publisher: Elsevier Masson SAS
Abstract: The increasing rate of cancer incidence has encouraged the search for novel natural sources of anticancer compounds. The presence of small quantities of taxol and taxanes in Corylus avellana L. has impelled new potential applications for this plant in the field of biomedicine. In the present work, the cell viability-reducing activity of stems and leaves from three different hazel trees was studied against three human-derived cancer cell lines (HeLa, HepG2 and MCF-7). Both leaf and stem extracts significantly reduced viability of the three cell lines either after maceration with methanol or using taxane extraction methods. Since maceration reduced cell viability to a greater extent than taxane extraction methods, we scaled up the maceration extraction process using a method for solid/liquid extraction (Zippertex technology). Methanol leaf extracts promoted a higher reduction in viability of all cell lines assayed than stem extracts. Fractionation of methanol leaf extracts using silica gel chromatography led to the purification and identification of two compounds by HPLC-MS and NMR: (3R,5R)-3,5-dihydroxy-1,7-bis(4-hydroxyphenyl) heptane 3-O-β-d-glucopyranoside and quercetin-3-O-rhamnoside. The isolated compounds decreased viability of HeLa and HepG2 cells to a greater extent than MCF-7 cells. Our results suggest a potential use of C. avellana extracts in the pharmacotherapy of cervical cancer and hepatocarcinoma and, to a lesser extent, breast cancer.
Note: Versió postprint del document publicat a:
It is part of: Biomedicine & Pharmacotherapy, 2017, vol. 89, p. 565-572
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ISSN: 0753-3322
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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