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http://hdl.handle.net/2445/114753
Title: | Advances in antibiotic therapy in the critically ill |
Author: | Vincent, Jean-Louis Bassetti, Matteo François, Bruno Karam, George Chastre, Jean Torres Martí, Antoni Roberts, Jason A. Taccone, Fabio Silvio Rello Condomines, Jordi Calandra, Thierry Backer, Daniel de Welte, Tobias Antonelli, Massimo |
Keywords: | Malalts en estat crític Antibiòtics Infeccions Critically ill Antibiotics Infections |
Issue Date: | 17-May-2016 |
Publisher: | BioMed Central |
Abstract: | Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high prevalence of antibiotic-resistant strains. In this review, we briefly discuss the importance of early infection diagnosis, before considering in more detail some of the key issues related to antibiotic management in these patients, including controversies surrounding use of combination or monotherapy, duration of therapy, and de-escalation. Antibiotic pharmacodynamics and pharmacokinetics, notably volumes of distribution and clearance, can be altered by critical illness and can influence dosing regimens. Dosing decisions in different subgroups of patients, e.g., the obese, are also covered. We also briefly consider ventilator-associated pneumonia and the role of inhaled antibiotics. Finally, we mention antibiotics that are currently being developed and show promise for the future. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s13054-016-1285-6 |
It is part of: | Critical Care, 2016, vol. 20, num. 1, p. 133 |
URI: | http://hdl.handle.net/2445/114753 |
Related resource: | https://doi.org/10.1186/s13054-016-1285-6 |
ISSN: | 1364-8535 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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