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http://hdl.handle.net/2445/122137
Title: | Molecular-subtype-specific biomarkers improve prediction of prognosis in colorectal cancer |
Author: | Bertram Bramsen, Jesper Heilskov Rasmussen, Mads Ongen, Halit Block Mattesen, Trine Worm Ørntoft, Mai-Britt Salling Árnadóttir, Sigrid Sandoval, Juan Laguna, Teresa Vang, Søren Øster, Bodil Lamy, Philippe Rørbæk Madsen, Mogens Laurberg, Søren Esteller, Manel Theophilos Dermitzakis, Emmanouil Falck Ørntoft, Torben Lindbjerg Andersen, Claus |
Keywords: | Marcadors bioquímics Pronòstic mèdic Càncer colorectal Cèl·lules canceroses Biochemical markers Prognosis Colorectal cancer Cancer cells |
Issue Date: | 9-May-2017 |
Publisher: | Elsevier |
Abstract: | Colorectal cancer (CRC) is characterized by major inter-tumor diversity that complicates the prediction of disease and treatment outcomes. Recent efforts help resolve this by sub-classification of CRC into natural molecular subtypes; however, this strategy is not yet able to provide clinicians with improved tools for decision making. We here present an extended framework for CRC stratification that specifically aims to improve patient prognostication. Using transcriptional profiles from 1,100 CRCs, including >300 previously unpublished samples, we identify cancer cell and tumor archetypes and suggest the tumor microenvironment as a major prognostic determinant that can be influenced by the microbiome. Notably, our subtyping strategy allowed identification of archetype-specific prognostic biomarkers that provided information beyond and independent of UICC-TNM staging, MSI status, and consensus molecular subtyping. The results illustrate that our extended subtyping framework, combining subtyping and subtype-specific biomarkers, could contribute to improved patient prognostication and may form a strong basis for future studies |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.celrep.2017.04.045 |
It is part of: | Cell Reports, 2017, vol. 19, num. 6, p. 1268-1280 |
URI: | http://hdl.handle.net/2445/122137 |
Related resource: | https://doi.org/10.1016/j.celrep.2017.04.045 |
ISSN: | 2211-1247 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
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