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DC Field | Value | Language |
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dc.contributor.author | Delahaye-Sourdeix, Manon | - |
dc.contributor.author | Oliver, Javier | - |
dc.contributor.author | Timofeeva, Maria N. | - |
dc.contributor.author | Gaborieau, Valérie | - |
dc.contributor.author | Johansson, Mattias | - |
dc.contributor.author | Chabrier, Amélie | - |
dc.contributor.author | Wozniak, Magdalena B. | - |
dc.contributor.author | Brenner, Darren R. | - |
dc.contributor.author | Vallee, Maxime P. | - |
dc.contributor.author | Anantharaman, Devasena | - |
dc.contributor.author | Lagiou, Pagona | - |
dc.contributor.author | Holcátová, Ivana | - |
dc.contributor.author | Richiardi, Lorenzo | - |
dc.contributor.author | Kjaerheim, Kristina | - |
dc.contributor.author | Agudo, Antonio | - |
dc.contributor.author | Castellsagué, Xavier | - |
dc.contributor.author | MacFarlane, Tatiana V. | - |
dc.contributor.author | Barzan, Luigi | - |
dc.contributor.author | Canova, Cristina | - |
dc.contributor.author | Thakker, Nalin S. | - |
dc.contributor.author | Conway, David I. | - |
dc.contributor.author | Znaor, Ariana | - |
dc.contributor.author | Healy, Claire M. | - |
dc.contributor.author | Ahrens, Wolfgang | - |
dc.contributor.author | Zaridze, David | - |
dc.contributor.author | Szeszenia-Dabrowska, Neonila | - |
dc.contributor.author | Lissowska, Jolanta | - |
dc.contributor.author | Fabianova, Eleonora | - |
dc.contributor.author | Mates, Ioan Nicolae | - |
dc.contributor.author | Bencko, Vladimir | - |
dc.contributor.author | Foretova, Lenka | - |
dc.contributor.author | Janout, Vladimir | - |
dc.contributor.author | Curado, Maria Paula | - |
dc.contributor.author | Koifman, Sergio | - |
dc.contributor.author | Menezes, Ana A. | - |
dc.contributor.author | Wünsch-Filho, Victor | - |
dc.contributor.author | Eluf Neto, José | - |
dc.contributor.author | Boffetta, Paolo | - |
dc.contributor.author | Fernández Garrote, Leticia | - |
dc.contributor.author | Serraino, Diego | - |
dc.contributor.author | Lener, Marcin | - |
dc.contributor.author | Jaworowska, Ewa | - |
dc.contributor.author | Lubinski, Jan | - |
dc.contributor.author | Boccia, Stefania | - |
dc.contributor.author | Rajkumar, Thangarajan | - |
dc.contributor.author | Samant, Tanuja A. | - |
dc.contributor.author | Mahimkar, Manoj B. | - |
dc.contributor.author | Matsuo, Keitaro | - |
dc.contributor.author | Franceschi, Silvia | - |
dc.contributor.author | Byrnes, Graham | - |
dc.contributor.author | Brennan, Paul | - |
dc.contributor.author | McKay, James D. | - |
dc.date.accessioned | 2018-09-06T07:36:42Z | - |
dc.date.available | 2018-09-06T07:36:42Z | - |
dc.date.issued | 2015-03-20 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124339 | - |
dc.description.abstract | Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0117639 | - |
dc.relation.ispartof | PLoS One, 2015, vol. 10, num. 3, p. e0117639 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0117639 | - |
dc.rights | cc by (c) Delahaye-Sourdeix et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de pulmó | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Lung cancer | - |
dc.subject.other | Gene expression | - |
dc.title | The 12p13.33/rad52 Locus And Genetic Susceptibility To Squamous Cell Cancers Of Upper Aerodigestive Tract | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:32:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25793373 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Delahaye-SourdeixM.pdf | 1.14 MB | Adobe PDF | View/Open |
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