Please use this identifier to cite or link to this item:
Title: Intramolecular fuzzy interactions involving intrinsically disordered domains
Author: Arbesú Andrés, Miguel
Iruela, Guillermo
Fuentes, Héctor
Teixeira, Joao M. C.
Pons Vallès, Miquel
Keywords: Proteïnes quinases
Protein kinases
Issue Date: 30-Apr-2018
Publisher: Frontiers Media
Abstract: Structural disorder is an essential ingredient for function in many proteins and protein complexes. Fuzzy complexes describe the many instances where disorder is maintained as a critical element of protein interactions. In this minireview we discuss how intramolecular fuzzy interactions function in signaling complexes. Focussing on the Src family of kinases, we argue that the intrinsically disordered domains that are unique for each of the family members and display a clear fingerprint of long range interactions in Src, might have critical roles as functional sensor or effectors and mediate allosteric communication via fuzzy interactions.
Note: Reproducció del document publicat a:
It is part of: Frontiers in Molecular Biosciences, 2018, vol. 5, p. 39
Related resource:
ISSN: 2296-889X
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

Files in This Item:
File Description SizeFormat 
682383.pdf608.38 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons