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Title: FOXP2 expression in frontotemporal lobar degeneration-tau
Author: López González, Irene
Palmeira, Andre
Aso Pérez, Ester
Carmona Murillo, Margarita
Fernandez, Liana
Ferrer, Isidro (Ferrer Abizanda)
Keywords: Factors de transcripció
Transcription factors
Issue Date: 6-Sep-2016
Publisher: IOS Press
Abstract: FOXP2 is altered in a variety of language disorders. We found reduced mRNA and protein expression of FOXP2 in frontal cortex area 8 in Pick's disease, and frontotemporal lobar degeneration-tau linked to P301L mutation presenting with language impairment in comparison with age-matched controls and cases with parkinsonian variant progressive supranuclear palsy. Foxp2 mRNA and protein are also reduced with disease progression in the somatosensory cortex in transgenic mice bearing the P301S mutation in MAPT when compared with wild-type littermates. Our findings support the presence of FOXP2 expression abnormalities in sporadic and familial frontotemporal degeneration tauopathies.
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It is part of: Journal of Alzheimer's Disease, 2016, vol. 54, p. 471-475
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ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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