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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/161243
Differentiation of multiple system atrophy from Parkinson's disease by structural connectivity derived from probabilistic tractography
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Recent studies combining difusion tensor-derived metrics and machine learning have shown promising results in the discrimination of multiple system atrophy (MSA) and Parkinson's disease (PD) patients. This approach has not been tested using more complex methodologies such as probabilistic tractography. The aim of this work is assessing whether the strength of structural connectivity between subcortical structures, measured as the number of streamlines (NOS) derived from tractography, can be used to classify MSA and PD patients at the single-patient level. The classifcation performance of subcortical FA and MD was also evaluated to compare the discriminant ability between difusion tensor-derived metrics and NOS. Using difusion-weighted images acquired in a 3T MRI scanner and probabilistic tractography, we reconstructed the white matter tracts between 18 subcortical structures from a sample of 54 healthy controls, 31 MSA patients and 65 PD patients. NOS between subcortical structures were compared between groups and entered as features into a machine learning algorithm. Reduced NOS in MSA compared with controls and PD were found in connections between the putamen, pallidum, ventral diencephalon, thalamus, and cerebellum, in both right and left hemispheres. The classifcation procedure achieved an overall accuracy of 78%, with 71% of the MSA subjects and 86% of the PD patients correctly classifed. NOS features outperformed the discrimination performance obtained with FA and MD. Our fndings suggest that structural connectivity derived from tractography has the potential to correctly distinguish between MSA and PD patients. Furthermore, NOS measures obtained from tractography might be more useful than difusion tensor-derived metrics for the detection of MSA.
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ABÓS, Alexandra, BAGGIO, Hugo césar, SEGURA I FÀBREGAS, Bàrbara, CAMPABADAL DELGADO, Anna, URIBE, Carme, GIRALDO, Darly m., PÉREZ SORIANO, Alexandra, MUÑOZ, Esteban, COMPTA, Yaroslau, JUNQUÉ I PLAJA, Carme, MARTÍ DOMÈNECH, Ma. josep. Differentiation of multiple system atrophy from Parkinson's disease by structural connectivity derived from probabilistic tractography. _Scientific Reports_. 2019. Vol. 9, núm. 1, pàgs. 16488. [consulta: 11 de desembre de 2025]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/161243]