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Title: Role of theobromine in cocoa's metabolic properties in healthy rats.
Author: Camps i Bossacoma, Mariona
Garcia Aloy, Mar
Saldaña-Ruíz, Sandra
Cambras Riu, Trinitat
González-Domínguez, Raúl
Franch i Masferrer, Àngels
Pérez-Cano, Francisco J.
Andrés Lacueva, Ma. Cristina
Castell, Margarida
Keywords: Pes corporal
Alimentació animal
Body weight
Animal feeding
Veterinary medicine
Issue Date: 11-Mar-2019
Publisher: American Chemical Society
Abstract: Cocoa is rich in polyphenols and methylxanthines and it has been reported that its consumption, among other properties, has beneficial effects on metabolism. This study aimed to investigate the role of theobromine in cocoa's metabolic properties in healthy rats. In addition to morphometric measurements, biochemical markers of lipids and glucose metabolism and gene expression of molecules related to immune cells in adipose and hepatic tissues were assessed after 7 or 18 days of diet. Additionally, a metabolomic analysis was carried out at day 7. This study revealed the presence of six discriminant metabolites in plasma due to the diets. Moreover, the results showed that theobromine is the main responsible factor for cocoa's effects on body weight gain as well as on lipid and glucose metabolism. The effects on body weight and lipids appeared as early as after 7 days of diet, whereas those affecting glucose metabolism required a longer intervention.
Note: Versió postprint del document publicat a:
It is part of: Journal of Agricultural and Food Chemistry, 2019, vol. 67, num. 13, p. 3605-3614
Related resource:
ISSN: 0021-8561
Appears in Collections:Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))
Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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