Please use this identifier to cite or link to this item:
Title: Cardiovascular risk factors and memory decline in middle-aged and older adults: the English Longitudinal Study of Ageing.
Author: Olaya Guzmán, Beatriz
Moneta, Maria Victoria
Bobak, Martin
Haro Abad, Josep Maria
Demakakos, Panayotes
Keywords: Sistema cardiovascular
Anàlisi de regressió
Persones de mitjana edat
Cardiovascular system
Regression analysis
Middle aged persons
Issue Date: 2-Dec-2019
Publisher: BioMed Central
Abstract: BACKGROUND: We investigated the association between trajectories of verbal episodic memory and burden of cardiovascular risk factors in middle-aged and older community-dwellers. METHODS: We analysed data from 4372 participants aged 50-64 and 3005 persons aged 65-79 years old from the English Longitudinal Study of Ageing who were repeatedly evaluated every 2 years and had six interviews of a 10-year follow-up. We measured the following baseline risk factors: diabetes, hypertension, smoking, physical inactivity and obesity to derive a cardiovascular risk factor score (CVRFs). Adjusted linear mixed effect regression models were estimated to determine the association between number of CVFRs and six repeated measurements of verbal memory scores, separately for middle-aged and older adults. RESULTS: CVRFs was not significantly associated with memory at baseline. CVFRs was significantly associated with memory decline in middle-aged (50-64y), but not in older (65-79y) participants. This association followed a dose-response pattern with increasing number of CVFRs being associated with greater cognitive decline. Comparisons between none versus some CVRFs yielded significant differences (p < 0.05). CONCLUSIONS: Our findings confirm that the effect of cumulative CVRFs on subsequent cognitive deterioration is age-dependent. CVRFs are associated with cognitive decline in people aged 50-64 years, but not in those aged ≥65 years. Although modest, the memory decline associated with accumulation of cardiovascular risk factors in midlife may increase the risk of late-life dementia.
Note: Reproducció del document publicat a:
It is part of: BMC Geriatrics, 2019, vol. 19, p. 337
Related resource:
ISSN: 1471-2318
Appears in Collections:Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
697621.pdf701.78 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons