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http://hdl.handle.net/2445/163703
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DC Field | Value | Language |
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dc.contributor.author | Almanza Aguilera, Enrique | - |
dc.contributor.author | Urpí Sardà, Mireia | - |
dc.contributor.author | Llorach, Rafael | - |
dc.contributor.author | Vázquez Fresno, Rosa | - |
dc.contributor.author | Garcia Aloy, Mar | - |
dc.contributor.author | Carmona Pontaque, Francesc | - |
dc.contributor.author | Sànchez, Àlex (Sànchez Pla) | - |
dc.contributor.author | Madrid Gambín, Francisco Javier | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.contributor.author | Corella Piquer, Dolores | - |
dc.contributor.author | Andrés Lacueva, Ma. Cristina | - |
dc.date.accessioned | 2020-06-02T10:25:50Z | - |
dc.date.available | 2020-06-02T10:25:50Z | - |
dc.date.issued | 2017-06-07 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.uri | http://hdl.handle.net/2445/163703 | - |
dc.description.abstract | The study of biomarkers of dietary patterns including the Mediterranean diet (MedDiet) is scarce and could improve the assessment of these patterns. Moreover, it could provide a better understanding of health benefits of dietary patterns in nutritional epidemiology. We aimed to determine a robust and accurate biomarker associated with a high adherence to a MedDiet pattern that included dietary assessment and its biological effect. In this cross-sectional study, we included 56 and 63 individuals with high (H-MDA) and low (L-MDA) MedDiet adherence categories, respectively, all from the Prevención con Dieta Mediterránea trial. A 1H-NMR-based untargeted metabolomics approach was applied to urine samples. Multivariate statistical analyses were conducted to determine the metabolite differences between groups. A stepwise logistic regression and receiver operating characteristic curves were used to build and evaluate the prediction model for H-MDA. Thirty-four metabolites were identified as discriminant between H-MDA and L-MDA. The fingerprint associated with H-MDA included higher excretion of proline betaine and phenylacetylglutamine, among others, and decreased amounts of metabolites related to glucose metabolism. Three microbial metabolites - phenylacetylglutamine, p-cresol and 4-hydroxyphenylacetate - were included in the prediction model of H-MDA (95% specificity, 95% sensitivity and 97% area under the curve). The model composed of microbial metabolites was the biomarker that defined high adherence to a Mediterranean dietary pattern. The overall metabolite profiling identified reflects the metabolic modulation produced by H-MDA. The proposed biomarker may be a better tool for assessing and aiding nutritional epidemiology in future associations between H-MDA and the prevention or amelioration of chronic diseases. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.jnutbio.2017.06.001 | - |
dc.relation.ispartof | Journal of Nutritional Biochemistry, 2017, vol. 48, p. 36-43 | - |
dc.relation.uri | https://doi.org/10.1016/j.jnutbio.2017.06.001 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Cuina mediterrània | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Hàbits alimentaris | - |
dc.subject.classification | Metabolòmica | - |
dc.subject.classification | Glutamina | - |
dc.subject.classification | Microbiota intestinal | - |
dc.subject.classification | Orina | - |
dc.subject.classification | Espectroscòpia de ressonància magnètica nuclear | - |
dc.subject.classification | Fisiologia | - |
dc.subject.other | Mediterranean cooking | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Food habits | - |
dc.subject.other | Metabolomics | - |
dc.subject.other | Glutamine | - |
dc.subject.other | Gastrointestinal microbiome | - |
dc.subject.other | Urine | - |
dc.subject.other | Nuclear magnetic resonance spectroscopy | - |
dc.subject.other | Physiology | - |
dc.title | Microbial metabolites are associated with a high adherence to a Mediterranean dietary pattern using a 1h-nmr-based untargeted metabolomics approach | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 672404 | - |
dc.date.updated | 2020-06-02T10:25:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB)) |
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672404.pdf | 1.39 MB | Adobe PDF | View/Open |
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