Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/173699
Title: Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice
Author: Van Hoecke, Lien
Riederer, Stephanie
Saelens, Xavier
Sutter, Gerd
Rojas, Juan J.
Keywords: Cèl·lules canceroses
Vacunes
Cancer cells
Vaccines
Issue Date: 1-Jan-2020
Publisher: Taylor & Francis
Abstract: Vaccinia viruses (VACV) are a novel class of immune-oncolytic therapeutics and their mechanism of action is based both on their capacity to replicate selectively in cancer cells and to elicit danger signals that can boost anti-tumor immunity. We recently reported that the intratumor expression of MLKL, a necroptosis inducing factor, generates a protective anti-tumor immunity. Here, we combined both approaches to test the use of VACV to deliver MLKL into the tumor. We generated VACV vectors expressing MLKL and evaluated the effects of MLKL on antitumor efficacy. In vitro infection of cancer cells with MLKL-expressing vectors led to cell death with necroptotic hallmarks. In syngeneic mouse tumor models, VACV expressing MLKL induced an outstanding antitumor activity, which was associated with a robust immunity directed against neo-epitopes. In conclusion, delivery of MLKL by VACV vectors boosts the intrinsic anti-tumor properties of these viral vectors by promoting in situ immunogenic cell death of infected cancer cells.
Note: Reproducció del document publicat a: https://doi.org/10.1080/2162402X.2020.1802968
It is part of: Oncoimmunology, 2020, vol. 9, num. 1, p. e1802968
URI: http://hdl.handle.net/2445/173699
Related resource: https://doi.org/10.1080/2162402X.2020.1802968
ISSN: 2162-402X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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