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Title: WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
Author: Rodriguez Hernandez, Irene
Maiques, Oscar
Kohlhammer, Leonie
Cantelli, Gaia
Perdrix Rosell, Anna
Monger, Joanne
Fanshawe, Bruce
Bridgeman, Victoria L.
Karagiannis, Sophia N.
Penín, Rosa
Marcolval, Joaquim
Marti, Rosa M.
Matias-Guiu, Xavier
Fruhwirth, Gilbert O.
Orgaz, Jose L.
Malanchi, Ilaria
Sanz Moreno, Victoria
Keywords: Melanoma
Issue Date: 20-Oct-2020
Publisher: Nature Research
Abstract: Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amoeboid melanoma cells. Mechanistically, we find that WNT11-FZD7-DAAM1 activates Rho-ROCK1/2-Myosin II and plays a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation. Importantly, amoeboid melanoma cells express both proliferative and invasive gene signatures. As such, invasive fronts of human and mouse melanomas are enriched in amoeboid cells that are also ki-67 positive. This pattern is further enhanced in metastatic lesions. We propose eradication of amoeboid melanoma cells after surgical removal as a therapeutic strategy. Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours.
Note: Reproducció del document publicat a:
It is part of: Nature Communications, 2020, vol. 11
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Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Publicacions de projectes de recerca finançats per la UE

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