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Title: An Esrrb and nanog cell fate regulatory module controlled by feed forward loop interactions
Author: Sevilla, Ana
Papatsenko, Dimitri
Mazloom, Amin R.
Xu, Huilei
Vasileva, Ana
Unwin, Richard D.
LeRoy, Gary
Chen, Edward Y.
Garrett-Bakelman, Francine E.
Lee, Dung-Fang
Trinite, Benjamin
Webb, Ryan L.
Wang, Zichen
Su, Jie
Gingold, Julian
Melnick, Ari
Garcia, Benjamin A.
Whetton, Anthony D.
MacArthur, Ben D.
Ma'ayan, Avi
Lemischka, Ihor R.
Keywords: Cèl·lules mare embrionàries
Receptors nuclears (Bioquímica)
Embryonic stem cells
Nuclear receptors (Biochemistry)
Issue Date: 26-Mar-2021
Publisher: Frontiers Media
Abstract: Cell fate decisions during development are governed by multi-factorial regulatory mechanisms including chromatin remodeling, DNA methylation, binding of transcription factors to specific loci, RNA transcription and protein synthesis. However, the mechanisms by which such regulatory 'dimensions' coordinate cell fate decisions are currently poorly understood. Here we quantified the multi-dimensional molecular changes that occur in mouse embryonic stem cells (mESCs) upon depletion of Estrogen related receptor beta (Esrrb), a key pluripotency regulator. Comparative analyses of expression changes subsequent to depletion of Esrrb or Nanog, indicated that a system of interlocked feed-forward loops involving both factors, plays a central part in regulating the timing of mESC fate decisions. Taken together, our meta-analyses support a hierarchical model in which pluripotency is maintained by an Oct4-Sox2 regulatory module, while the timing of differentiation is regulated by a Nanog-Esrrb module.
Note: Reproducció del document publicat a:
It is part of: Frontiers In Cell And Developmental Biology, 2021, vol. 9, p. 630067
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ISSN: 2296-634X
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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