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703048.pdf (793.43 KB)

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2020-08-06

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cc-by (c) Silva Ribeiro, Joana et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/176668

Risk Calculators in Bipolar Disorder: A Systematic Review

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https://doi.org/10.3390/brainsci10080525

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Introduction: Early recognition of bipolar disorder improves the prognosis and decreases the burden of the disease. However, there is a significant delay in diagnosis. Multiple risk factors for bipolar disorder have been identified and a population at high-risk for the disorder has been more precisely defined. These advances have allowed the development of risk calculators to predict individual risk of conversion to bipolar disorder. This review aims to identify the risk calculators for bipolar disorder and assess their clinical applicability. Methods: A systematic review of original studies on the development of risk calculators in bipolar disorder was performed. The studies' quality was evaluated with the Newcastle-Ottawa Quality Assessment Form for Cohort Studies and according to recommendations of the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis Initiative. Results: Three studies met the inclusion criteria; one developed a risk calculator of conversion from major depressive episode to bipolar disorder; one of conversion to new-onset bipolar spectrum disorders in offspring of parents with bipolar disorder; and the last one of conversion in youths with bipolar disorder not-otherwise-specified. Conclusions: The calculators reviewed in this article present good discrimination power for bipolar disorder, although future replication and validation of the models is needed.

Matèries

Trastorn bipolar, Avaluació del risc per la salut, Ressenyes sistemàtiques (Investigació mèdica)

Matèries (anglès)

Manic-depressive illness, Health risk assessment, Systematic reviews (Medical research)

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Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

SILVA RIBEIRO, Joana, PEREIRA, Daniela, SALAGRE MUÑOZ, Estela, COROA, Manuel, SANTOS OLIVEIRA, Pedro, SANTOS, Vítor, MADEIRA, Nuno, GRANDE I FULLANA, Iria, VIETA I PASCUAL, Eduard. Risk Calculators in Bipolar Disorder: A Systematic Review. _Brain Sciences_. 2020. Vol. 10, núm. 8, pàgs. 525. [consulta: 7 de gener de 2026]. ISSN: 2076-3425. [Disponible a: https://hdl.handle.net/2445/176668]

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