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Title: Risk Calculators in Bipolar Disorder: A Systematic Review
Author: Silva Ribeiro, Joana
Pereira, Daniela
Salagre, Estela
Coroa, Manuel
Santos Oliveira, Pedro
Santos, Vítor
Madeira, Nuno
Grande i Fullana, Iria
Vieta i Pascual, Eduard, 1963-
Keywords: Trastorn bipolar
Avaluació del risc per la salut
Ressenyes sistemàtiques (Investigació mèdica)
Manic-depressive illness
Health risk assessment
Systematic reviews (Medical research)
Issue Date: 6-Aug-2020
Publisher: MDPI
Abstract: Introduction: Early recognition of bipolar disorder improves the prognosis and decreases the burden of the disease. However, there is a significant delay in diagnosis. Multiple risk factors for bipolar disorder have been identified and a population at high-risk for the disorder has been more precisely defined. These advances have allowed the development of risk calculators to predict individual risk of conversion to bipolar disorder. This review aims to identify the risk calculators for bipolar disorder and assess their clinical applicability. Methods: A systematic review of original studies on the development of risk calculators in bipolar disorder was performed. The studies' quality was evaluated with the Newcastle-Ottawa Quality Assessment Form for Cohort Studies and according to recommendations of the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis Initiative. Results: Three studies met the inclusion criteria; one developed a risk calculator of conversion from major depressive episode to bipolar disorder; one of conversion to new-onset bipolar spectrum disorders in offspring of parents with bipolar disorder; and the last one of conversion in youths with bipolar disorder not-otherwise-specified. Conclusions: The calculators reviewed in this article present good discrimination power for bipolar disorder, although future replication and validation of the models is needed.
Note: Reproducció del document publicat a:
It is part of: Brain Sciences, 2020, vol. 10, num. 8, p. 525
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ISSN: 2076-3425
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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