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Title: Epigenetic-smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early‐stage NSCLC patients
Author: Ji, Xinyu
Lin, Lijuan
Shen, Sipeng
Dong, Xuesi
Chen, Chao
Li, Yi
Zhu, Ying
Huang, Hui
Chen, Jiajin
Chen, Xin
Wei, Liangmin
He, Jieyu
Duan, Weiwei
Su, Li
Jiang, Yue
Fan, Juanjuan
Guan, Jinxing
You, Dongfang
Shafer, Andrea
Moksnes-Bjaanæs, Maria
Karlsson, Anna
Planck, Maria
Staaf, Johan
Helland, Åslaug
Esteller, Manel
Wei, Yongyue
Zhang, Ruyang
Chen, Feng
Christiani, David C.
Keywords: ADN
Càncer de pulmó
Pronòstic mèdic
Lung cancer
Issue Date: 1-Nov-2020
Publisher: Elsevier
Abstract: Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylation of TRIM27 and overall survival. Significant CpG probes were confirmed in 617 samples from The Cancer Genome Atlas. The methylation of the CpG probe cg05293407TRIM27 was significantly associated with overall survival in patients with LUSC (HR = 1.65, 95% CI: 1.30-2.09, P = 4.52 × 10-5), but not in patients with LUAD (HR = 1.08, 95% CI: 0.87-1.33, P = 0.493). As incidence of LUSC is associated with higher smoking intensity compared to LUAD, we investigated whether smoking intensity impacted on the prognostic effect of cg05293407TRIM27 methylation in NSCLC. LUSC patients had a higher average pack-year of smoking (37.49LUAD vs 54.79LUSC, P = 1.03 × 10-19) and included a higher proportion of current smokers than LUAD patients (28.24%LUAD vs 34.09%LUSC, P = 0.037). cg05293407TRIM27 was significantly associated with overall survival only in NSCLC patients with medium-high pack-year of smoking (HR = 1.58, 95% CI: 1.26-1.96, P = 5.25 × 10-5). We conclude that cg05293407TRIM27 methylation is a potential predictor of LUSC prognosis, and smoking intensity may impact on its prognostic value across the various types of NSCLC.
Note: Reproducció del document publicat a:
It is part of: Molecular Oncology, 2020, vol. 14, num. 11, p. 2759-2774
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ISSN: 1574-7891
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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