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Title: | Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study |
Author: | García Escobar, Eva Valdés, Sergio Soriguer, Federico Vendrell, Joan Urrutia Etxebarria, Inés María Maldonado-araque, Cristina Ortega, Emilio Ocón, Pilar Montanya Mias, Eduard Menendez, Eldelmiro Lago Sampedro, Ana González Frutos, Teba Gomis, Ramon, 1946- Goday Arnó, Albert García Serrano, Sara Galán García, José Luís Castell, Conxa Bordiú, Elena Badía Guillén, Rocío Aguilera Venegas, Gabriel Girbés Borrás, Juan Adrián Gaztambide, Sonia Delgado Álvarez, Elías Chaves, Felipe Javier Castaño, Luis Calle Pascual, Alfonso L. Rojo Martínez, Gemma Franch Nadal, Josep |
Keywords: | Diabetis Malalties del fetge Diabetes Liver diseases |
Issue Date: | 12-Aug-2021 |
Publisher: | Springer Science and Business Media LLC |
Abstract: | Our aim was to evaluate whether fatty liver index (FLI) is associated with the risk of type 2 diabetes (T2DM) development within the Spanish adult population and according to their prediabetes status; additionally, to examine its incremental predictive value regarding traditional risk factors. A total of 2260 subjects (Prediabetes: 641 subjects, normoglycemia: 1619 subjects) from the Di@bet.es cohort study were studied. Socio-demographic, anthropometric, clinical data and survey on habits were recorded. An oral glucose tolerance test was performed and fasting determinations of glucose, lipids and insulin were made. FLI was calculated and classified into three categories: Low (< 30), intermediate (30-60) and high (> 60). In total, 143 people developed diabetes at follow-up. The presence of a high FLI category was in all cases a significant independent risk factor for the development of diabetes. The inclusion of FLI categories in prediction models based on different conventional T2DM risk factors significantly increase the prediction power of the models when all the population was considered. According to our results, FLI might be considered an early indicator of T2DM development even under normoglycemic condition. The data also suggest that FLI could provide additional information for the prediction of T2DM in models based on conventional risk factors. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-95546-x |
It is part of: | Scientific Reports, 2021, vol. 11, num. 1 |
URI: | http://hdl.handle.net/2445/179954 |
Related resource: | https://doi.org/10.1038/s41598-021-95546-x |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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s41598-021-95546-x.pdf | 1.08 MB | Adobe PDF | View/Open |
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