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biomedicines-09-01344.pdf (1.72 MB)

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2021-09-28

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cc by (c) Illa Armengol, Míriam et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/180646

Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model

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https://doi.org/10.3390/biomedicines9101344

Resum

Perinatal asphyxia is a major cause of severe brain damage and death. For its prenatal identification, Doppler ultrasound has been used as a surrogate marker of fetal hypoxia. However, Doppler evaluation cannot be performed continuously. We have evaluated the performance of a miniaturized multiparametric sensor aiming to evaluate tissular oxygen and pH changes continuously in an umbilical cord occlusion (UCO) sheep model. The electrochemical sensors were inserted in fetal hindlimb skeletal muscle and electrochemical signals were recorded. Fetal hemodynamic changes and metabolic status were also monitored during the experiment. Additionally, histological assessment of the tissue surrounding the sensors was performed. Both electrochemical sensors detected the pO2 and pH changes induced by the UCO and these changes were correlated with hemodynamic parameters as well as with pH and oxygen content in the blood. Finally, histological assessment revealed no signs of alteration on the same day of insertion. This study provides the first evidence showing the application of miniaturized multiparametric electrochemical sensors detecting changes in oxygen and pH in skeletal muscular tissue in a fetal sheep model.

Matèries

Medicina prenatal, Asfíxia, Monitoratge fetal

Matèries (anglès)

Prenatal medicine, Asphyxia, Fetal monitoring

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Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

ILLA ARMENGOL, Míriam, PLA, Laura, BERDÚN MARIN, Sergio, MIR LLORENTE, Mònica, RIVAS, Lourdes, DULAY, Samuel, PICARD HAGEN, Nicole, SAMITIER I MARTÍ, Josep, GRATACÓS SOLSONA, Eduard, EIXARCH ROCA, Elisenda. Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model. _Biomedicines_. 2021. Vol.  vol 9, núm. 10, pàgs. 1344. [consulta: 9 de gener de 2026]. ISSN: 2227-9059. [Disponible a: https://hdl.handle.net/2445/180646]

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