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http://hdl.handle.net/2445/183725
Title: | Purinergic signaling in endometriosis-associated pain |
Author: | Trapero, Carla Martín Satué, Mireia |
Keywords: | Endometriosi Adenosina Dolor Inflamació Endometriosis Adenosine Pain Inflammation |
Issue Date: | 12-Nov-2020 |
Publisher: | MDPI |
Abstract: | Endometriosis is an estrogen-dependent gynecological disease, with an associated chronic inflammatory component, characterized by the presence of endometrial tissue outside the uterine cavity. Its predominant symptom is pain, a condition notably altering the quality of life of women with the disease. This review is intended to exhaustively gather current knowledge on purinergic signaling in endometriosis-associated pain. Altered extracellular ATP hydrolysis, due to changes in ectonucleotidase activity, has been reported in endometriosis; the resulting accumulation of ATP in the endometriotic microenvironment points to sustained activation of nucleotide receptors (P2 receptors) capable of generating a persistent pain message. P2X3 receptor, expressed in sensory neurons, mediates nociceptive, neuropathic, and inflammatory pain, and is enrolled in endometriosis-related pain. Pharmacological inhibition of P2X3 receptor is under evaluation as a pain relief treatment for women with endometriosis. The role of other ATP receptors is also discussed here, e.g., P2X4 and P2X7 receptors, which are involved in inflammatory cell-nerve and microglia-nerve crosstalk, and therefore in inflammatory and neuropathic pain. Adenosine receptors (P1 receptors), by contrast, mainly play antinociceptive and anti-inflammatory roles. Purinome-targeted drugs, including nucleotide receptors and metabolizing enzymes, are potential non-hormonal therapeutic tools for the pharmacological management of endometriosis-related pain. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms21228512 |
It is part of: | International Journal of Molecular Sciences, 2020, vol. 21, num. 22, p. 8512 |
URI: | http://hdl.handle.net/2445/183725 |
Related resource: | https://doi.org/10.3390/ijms21228512 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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