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Title: Aggregation versus Biological Activity in Gold(I) Complexes. An Unexplored Concept
Author: Pinto Martínez, Andrea
Roma-Rodrigues, C.
Ward, J.S.
Puttreddy, R.
Baptista, P.V.
Fernandes, A.R.
Lima, J.C.
Rodríguez Raurell, Laura
Keywords: Or
Raigs X
Agregació (Química)
Aggregation (Chemistry)
Issue Date: 2021
Publisher: American Chemical Society
Abstract: The aggregation process of a series of mono- and dinuclear gold(I) complexes containing a 4-ethynylaniline ligand and a phosphane at the second coordination position (PR3-Au-C≡CC6H4-NH2, complexes 1-5, and (diphos)(Au-C≡CC6H4-NH2)2, complexes 6-8), whose biological activity was previously studied by us, has been carefully analyzed through absorption, emission, and NMR spectroscopy, together with dynamic light scattering and small-angle X-ray scattering. These experiments allow us to retrieve information about how the compounds enter the cells. It was observed that all compounds present aggregation in fresh solutions, before biological treatment, and thus they must be entering the cells as aggregates. Inductively coupled plasma atomic emission spectrometry measurements showed that mononuclear complexes are mainly found in the cytosolic fraction; the dinuclear complexes are mainly found in a subsequent fraction composed of nuclei and cytoskeleton. Additionally, dinuclear complex 8 affects the actin aggregation to a larger extent, suggesting a cooperative effect of dinuclear compounds.
Note: Versió postprint del document publicat a:
It is part of: Inorganic Chemistry, 2021, vol. 60, num. 24, p. 18753-18763
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ISSN: 0020-1669
Appears in Collections:Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Química Inorgànica i Orgànica)

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