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1977

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/18642

Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis

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Recurs relacionat

http://dx.doi.org/10.1136/gut.18.7.556

Resum

Forty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none of the 21 with normal renal function (P less than 0-01). A positive Limulus test was almost exclusively associated with a progressive FRF (eight of 10 patients) and all but one of them died. Renal function improved as endotoxaemia disappeared in the survivor. Endotoxaemia was also associated with haemorrhage due to acute erosions of the gastric mucosa, being present in six of the seven patients who had this complication. Intravascular coagulation was not found in any patient. The Limulus test was positive in the ascitic fluid in 18 of 21 patients tested, although only two of them had peritonitis. These results suggest that endotoxaemia may play a critical role in the development of progressive renal failure and haemorrhagic gastritis in cirrhosis, and emphasise the potential risk of procedures involving reinfusion of ascitic fluid.

Matèries

Insuficiència renal aguda, Cirrosi hepàtica, Hemorràgia gastrointestinal, Endotoxines, Gastritis

Matèries (anglès)

Hepatic cirrhosis, Acute renal failure, Gastritis, Gastrointestinal hemorrhage, Endotoxins

Citació

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Articles publicats en revistes (Medicina)

Citació

CLEMENTE, C., BOSCH I GENOVER, Jaume, RODÉS, J., ARROYO, Vicente, MAS COMAS, Ana m., MARAGALL, S.. Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis. _Gut_. 1977. Vol. 18, núm. 7, pàgs. 556-560. [consulta: 1 de gener de 2026]. ISSN: 0017-5749. [Disponible a: https://hdl.handle.net/2445/18642]

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