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Title: Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE)
Author: Carbonell Abella, Cristina
Marcos, Miguel
Guillén del Castillo, Alfredo
Rubio Rivas, Manuel
Argibay, Ana
Marín Ballvé, Adela
Rodríguez Pintó, Ignasi
Baldà Masmiquel, Maria
Callejas Moraga, Eduardo
Colunga Argüelles, Dolores
Sáez Comet, Luis
González Echávarri, Cristina
Ortego Centeno, Norberto
Marí Alfonso, Begoña
Vargas Hitos, José Antonio
Todolí Parra, José Antonio
Trapiella, Luis
Herranz Marín, María Teresa
Freire, Mayka
Castro Salomó, Antoni
Perales Fraile, Isabel
Madroñero Vuelta, Ana Belén
Sánchez García, María Esther
Ruiz Muñoz, Manuel
González García, Andrés
Sánchez Redondo, Jorge
De la Red Bellvis, Gloria
Fernández Luque, Alejandra
Muela Molinero, Alberto
Lledó, Gema
Tolosa Vilella, Carles
Fonollosa Pla, Vicent
Chamorro, Antonio Javier
Simeón Aznar, Carmen Pilar
Keywords: Càncer
Issue Date: 1-Oct-2022
Publisher: Elsevier BV
Abstract: Aim: Patients with systemic sclerosis (SSc) are at increased risk of cancer, a growing cause of non-SSc-related death among these patients. We analyzed the increased cancer risk among Spanish patients with SSc using standardized incidence ratios (SIRs) and identified independent cancer risk factors in this population. Material and methods: Spanish Scleroderma Registry data were analyzed to determine the demographic characteristics of patients with SSc, and logistic regression was used to identify cancer risk factors. SIRs with 95% confidence intervals (CIs) relative to the general Spanish population were calculated. Results: Of 1930 patients with SSc, 206 had cancer, most commonly breast, lung, hematological, and colorectal cancers. Patients with SSc had increased risks of overall cancer (SIR 1.48, 95% CI 1.36-1.60; P < 0.001), and of lung (SIR 2.22, 95% CI 1.77-2.73; P < 0.001), breast (SIR 1.31, 95% CI 1.10-1.54; P = 0.003), and hematological (SIR 2.03, 95% CI 1.52-2.62; P < 0.001) cancers. Cancer was associated with older age at SSc onset (odds ratio [OR] 1.22, 95% CI 1.01-1.03; P < 0.001), the presence of primary biliary cholangitis (OR 2.35, 95% CI 1.18-4.68; P = 0.015) and forced vital capacity <70% (OR 1.8, 95% CI 1.24-2.70; P = 0.002). The presence of anticentromere antibodies lowered the risk of cancer (OR 0.66, 95% CI 0.45-0.97; P = 0.036). Conclusions: Spanish patients with SSc had an increased cancer risk compared with the general population. Some characteristics, including specific autoantibodies, may be related to this increased risk.
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It is part of: Autoimmunity Reviews, 2022, vol. 21, núm. 10, p. 103167
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ISSN: 1873-0183
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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