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Title: | Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE) |
Author: | Carbonell Abella, Cristina Marcos, Miguel Guillén del Castillo, Alfredo Rubio Rivas, Manuel Argibay, Ana Marín Ballvé, Adela Rodríguez Pintó, Ignasi Baldà Masmiquel, Maria Callejas Moraga, Eduardo Colunga Argüelles, Dolores Sáez Comet, Luis González Echávarri, Cristina Ortego Centeno, Norberto Marí Alfonso, Begoña Vargas Hitos, José Antonio Todolí Parra, José Antonio Trapiella, Luis Herranz Marín, María Teresa Freire, Mayka Castro Salomó, Antoni Perales Fraile, Isabel Madroñero Vuelta, Ana Belén Sánchez García, María Esther Ruiz Muñoz, Manuel González García, Andrés Sánchez Redondo, Jorge De la Red Bellvis, Gloria Fernández Luque, Alejandra Muela Molinero, Alberto Lledó, Gema Tolosa Vilella, Carles Fonollosa Pla, Vicent Chamorro, Antonio Javier Simeón Aznar, Carmen Pilar |
Keywords: | Càncer Cancer |
Issue Date: | 1-Oct-2022 |
Publisher: | Elsevier BV |
Abstract: | Aim: Patients with systemic sclerosis (SSc) are at increased risk of cancer, a growing cause of non-SSc-related death among these patients. We analyzed the increased cancer risk among Spanish patients with SSc using standardized incidence ratios (SIRs) and identified independent cancer risk factors in this population. Material and methods: Spanish Scleroderma Registry data were analyzed to determine the demographic characteristics of patients with SSc, and logistic regression was used to identify cancer risk factors. SIRs with 95% confidence intervals (CIs) relative to the general Spanish population were calculated. Results: Of 1930 patients with SSc, 206 had cancer, most commonly breast, lung, hematological, and colorectal cancers. Patients with SSc had increased risks of overall cancer (SIR 1.48, 95% CI 1.36-1.60; P < 0.001), and of lung (SIR 2.22, 95% CI 1.77-2.73; P < 0.001), breast (SIR 1.31, 95% CI 1.10-1.54; P = 0.003), and hematological (SIR 2.03, 95% CI 1.52-2.62; P < 0.001) cancers. Cancer was associated with older age at SSc onset (odds ratio [OR] 1.22, 95% CI 1.01-1.03; P < 0.001), the presence of primary biliary cholangitis (OR 2.35, 95% CI 1.18-4.68; P = 0.015) and forced vital capacity <70% (OR 1.8, 95% CI 1.24-2.70; P = 0.002). The presence of anticentromere antibodies lowered the risk of cancer (OR 0.66, 95% CI 0.45-0.97; P = 0.036). Conclusions: Spanish patients with SSc had an increased cancer risk compared with the general population. Some characteristics, including specific autoantibodies, may be related to this increased risk. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.autrev.2022.103167 |
It is part of: | Autoimmunity Reviews, 2022, vol. 21, núm. 10, p. 103167 |
URI: | https://hdl.handle.net/2445/190186 |
Related resource: | https://doi.org/10.1016/j.autrev.2022.103167 |
ISSN: | 1873-0183 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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