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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/199582
Differences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss
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Obesity and asthma are associated with systemic inflammation maintained by mediators released by adipose tissue and lung. This study investigated the inflammatory serum mediator profile in obese subjects (O) (n = 35), non-obese asthma (NOA) patients (n = 14), obese asthmatics (OA) (n = 21) and healthy controls (HC) (n = 33). The effect of weight loss after bariatric surgery (BS) was examined in 10 OA and 31 O subjects. We analyzed serum markers including leptin, adiponectin, TGF-?1, TNFR2, MCP-1, ezrin, YKL-40, ST2, IL-5, IL-9, and IL-18. Compared with HC subjects, the O group showed increased levels of leptin, TGF-?1, TNFR2, MCP-1, ezrin, YKL-40, and ST2; the OA group presented increased levels of MCP-1, ezrin, YKL-40, and IL-18, and the NOA group had increased levels of ezrin, YKL-40, IL-5, and IL-18. The higher adiponectin/leptin ratio in NOA with respect to OA subjects was the only significant difference between the two groups. IL-9 was the only cytokine with significantly higher levels in OA with respect to O subjects. TNFR2, ezrin, MCP-1, and IL-18 concentrations significantly decreased in O subjects after BS. O, OA, and NOA showed distinct patterns of systemic inflammation. Leptin and adiponectin are regulated in asthma by obesity-dependent and-independent mechanisms. Combination of asthma and obesity does not result in significant additive effects on circulating cytokine levels. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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BANTULÀ, Marina, TUBITA, Valeria, ROCA FERRER, Jordi, MULLOL I MIRET, Joaquim, VALERO, Antonio, BOBOLEA, Irina, PASCAL I CAPDEVILA, Mariona, HOLLANDA RAMÍREZ, Ana m. de, VIDAL, Josep, PICADO VALLÉS, César, ARISMENDI, Ebymar. Differences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss. _Journal Of Clinical Medicine_. 2022. Vol. 11, núm. 13. [consulta: 4 de desembre de 2025]. ISSN: 2077-0383. [Disponible a: https://hdl.handle.net/2445/199582]