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Differences in Inflammatory Cytokine Profile in_ClinicalMedicine.pdf (1.03 MB)

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2022-06-29

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cc by (c) Bantulà, Marina et al, 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/199582

Differences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss

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https://doi.org/10.3390/jcm11133782

Resum

Obesity and asthma are associated with systemic inflammation maintained by mediators released by adipose tissue and lung. This study investigated the inflammatory serum mediator profile in obese subjects (O) (n = 35), non-obese asthma (NOA) patients (n = 14), obese asthmatics (OA) (n = 21) and healthy controls (HC) (n = 33). The effect of weight loss after bariatric surgery (BS) was examined in 10 OA and 31 O subjects. We analyzed serum markers including leptin, adiponectin, TGF-?1, TNFR2, MCP-1, ezrin, YKL-40, ST2, IL-5, IL-9, and IL-18. Compared with HC subjects, the O group showed increased levels of leptin, TGF-?1, TNFR2, MCP-1, ezrin, YKL-40, and ST2; the OA group presented increased levels of MCP-1, ezrin, YKL-40, and IL-18, and the NOA group had increased levels of ezrin, YKL-40, IL-5, and IL-18. The higher adiponectin/leptin ratio in NOA with respect to OA subjects was the only significant difference between the two groups. IL-9 was the only cytokine with significantly higher levels in OA with respect to O subjects. TNFR2, ezrin, MCP-1, and IL-18 concentrations significantly decreased in O subjects after BS. O, OA, and NOA showed distinct patterns of systemic inflammation. Leptin and adiponectin are regulated in asthma by obesity-dependent and-independent mechanisms. Combination of asthma and obesity does not result in significant additive effects on circulating cytokine levels. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Matèries

Asma, Obesitat

Matèries (anglès)

Asthma, Obesity

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

BANTULÀ, Marina, TUBITA, Valeria, ROCA FERRER, Jordi, MULLOL I MIRET, Joaquim, VALERO, Antonio, BOBOLEA, Irina, PASCAL I CAPDEVILA, Mariona, HOLLANDA RAMÍREZ, Ana m. de, VIDAL, Josep, PICADO VALLÉS, César, ARISMENDI, Ebymar. Differences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss. _Journal Of Clinical Medicine_. 2022. Vol. 11, núm. 13. [consulta: 3 de gener de 2026]. ISSN: 2077-0383. [Disponible a: https://hdl.handle.net/2445/199582]

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