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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/208298
Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells
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The functional complementarity of the vestibulo-ocular reflex (VOR) and optokinetic reflex (OKR) allows for optimal combined gaze stabilization responses (CGR) in light. While sensory substitution has been reported following complete vestibular loss, the capacity of the central vestibular system to compensate for partial peripheral vestibular loss remains to be determined. Here, we first demonstrate the efficacy of a 6-week subchronic ototoxic protocol in inducing transient and partial vestibular loss which equally affects the canal- and otolith-dependent VORs. Immunostaining of hair cells in the vestibular sensory epithelia revealed that organ-specific alteration of type I, but not type II, hair cells correlates with functional impairments. The decrease in VOR performance is paralleled with an increase in the gain of the OKR occurring in a specific range of frequencies where VOR normally dominates gaze stabilization, compatible with a sensory substitution process. Comparison of unimodal OKR or VOR versus bimodal CGR revealed that visuo-vestibular interactions remain reduced despite a significant recovery in the VOR. Modeling and sweep-based analysis revealed that the differential capacity to optimally combine OKR and VOR correlates with the reproducibility of the VOR responses. Overall, these results shed light on the multisensory reweighting occurring in pathologies with fluctuating peripheral vestibular malfunction.
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LLORENS LLACUNA, Joan, SCHENBERG, Louise, PALOU, Aïda, SIMON, François, BONNARD, Tess, BARTON, Charles-elliot, FRICKER, Desdemona, TAGLIABUE, Michele, BERANECK, Mathieu. Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells. _eLife_. 2023. Vol. 12, núm. RP88819. [consulta: 10 de desembre de 2025]. ISSN: 2050-084X. [Disponible a: https://hdl.handle.net/2445/208298]