Miniatura

Fitxers

250928.pdf (3.15 MB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2022-06-13

Llicència de publicació

cc-by-nc-nd (c) Elsevier, 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/216880

Genetic and Structural Brain Correlates of Cognitive Subtypes Across Youth at Family Risk for Schizophrenia and Bipolar Disorder

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.jaac.2022.05.011

Resum

Objective: Cognitive impairment is an important feature of schizophrenia (SZ) and bipolar disorder (BP) with severity across the two disorders characterized by significant heterogeneity. Youth at family risk for SZ and BP were clustered based on cognitive function and examined in terms of the clinical, genetic, and brain imaging correlates of cluster membership. Method: One hundred sixty participants, 32 offspring of patients with SZ, 59 offspring of patients with BP and 69 offspring of healthy control parents underwent clinical and cognitive assessments, genotyping and structural MRI. K-means clustering was used to group family risk participants based on cognitive measures. Clusters were compared in terms of cortical and subcortical brain measures as well as polygenic risk scores. Results: Participants were grouped in 3 clusters with intact, intermediate, and impaired cognitive performance. The intermediate and impaired clusters had lower total brain surface area compared with the intact cluster, with prominent localization in frontal and temporal cortices. No between-cluster differences were identified in cortical thickness and subcortical brain volumes. The impaired cluster also had poorer psychosocial functioning and worse PRS-COG compared with the other 2 clusters and with offspring of healthy control parents, while there was no significant between-cluster difference in terms of PRS-SZ and PRS-BP. PRS-COG predicted psychosocial functioning, yet this effect did not appear to be mediated by an effect of PRS-COG on brain area. Conclusion: Stratification based on cognition may help to elucidate the biological underpinnings of cognitive heterogeneity across SZ and BP risk.

Descripció

Matèries

Esquizofrènia, Factors de risc en les malalties, Ressonància magnètica nuclear, Infants, Trastorn bipolar

Matèries (anglès)

Schizophrenia, Risk factors in diseases, Nuclear magnetic resonance, Children, Manic-depressive illness

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

VALLI, Isabel, SERNA, Elena de la, SEGURA, Alex g., PARIENTE, Jose carlos, CALVET, Àngels, BORRAS, Roger, ILZARBE, Daniel, MORENO, Davinia, MARTÍN MARTÍNEZ, Nuria, BAEZA, Inmaculada, ROSA JUSTICIA, Mireia, GARCÍA RIZO, Clemente, DÍAZ CANEJA, Covadonga m., CROSSLEY, Nicholas a., YOUNG, Allan h., VIETA I PASCUAL, Eduard, MAS, Sergi, CASTRO FORNIELES, Josefina, SUGRANYES, Gisela. Genetic and Structural Brain Correlates of Cognitive Subtypes Across Youth at Family Risk for Schizophrenia and Bipolar Disorder. _Journal of the American Academy of Child and Adolescent Psychiatry_. 2022. Vol. 62, núm. 1, pàgs. 74-83. [consulta: 11 de desembre de 2025]. ISSN: 0890-8567. [Disponible a: https://hdl.handle.net/2445/216880]

Exportar metadades

JSON - METS

Compartir registre