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2000

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/22453

Circulating concentrations of soluble L-selectin (CD62L) in patients with primary Sjögren's syndrome.

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http://dx.doi.org/10.1136/ard.59.4.297

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OBJECTIVE—Serum concentrations of soluble (s) L-selectin (CD62L) were measured in patients with primary Sjögren's syndrome (SS) to relate these concentrations to clinical and immunological features of SS.
METHODS—The study included 40 consecutive patients (38 women and two men) with a mean age of 61 years (range 24-78) who fulfilled four or more of the preliminary diagnostic criteria for SS proposed by the European Community Study Group in 1993, and 33 healthy blood donors from the hospital blood bank. A sandwich enzyme linked immunosorbent assay (ELISA) was used to detect the soluble form of human sL-selectin (CD62L).
RESULTS—The mean (SEM) values of sL-selectin (CD62L) were 861 (66) µg/ml for patients with SS and 986 (180) µg/ml for healthy blood donors, but there was no significant difference. In patients with primary SS, serum sL-selectin (CD62L) concentrations were significantly higher in patients with Raynaud's phenomenon (1275 (112) µg/ml versus 789 (69) µg/ml, p=0.007), autoimmune thyroiditis (1162 (113) µg/ml versus 787 (69) µg/ml, p=0.02) and rheumatoid factor (993 (95) µg/ml versus 684 (70) µg/ml, p=0.01) when compared with patients without these features.
CONCLUSION—The presence of Raynaud's phenomenon, autoimmune thyroiditis and rheumatoid factor is associated with higher concentrations of circulating sL-selectin (CD62L) in the sera of patients with primary SS.



Matèries

Proteïnes, Receptors cel·lulars, Síndrome de Sjögren, Leucòcits

Matèries (anglès)

Proteins, Cell receptors, Sjogren's syndrome, Leucocytes

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Articles publicats en revistes (Medicina)

Citació

GARCÍA CARRASCO, Mario, PIZCUETA LALANZA, María pilar, CERVERA I SEGURA, Ricard, RAMOS CASALS, Manuel, SISÓ ALMIRALL, Antoni, RED, Gloria de la, INGELMO MORÍN, Miguel, FONT FRANCO, Josep, ENGEL ROCAMORA, Pablo. Circulating concentrations of soluble L-selectin (CD62L) in patients with primary Sjögren's syndrome.. _Annals of the Rheumatic Diseases_. 2000. Vol. 59, núm. núm 4, pàgs. 297-299. [consulta: 27 de desembre de 2025]. ISSN: 0003-4967. [Disponible a: https://hdl.handle.net/2445/22453]

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