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Title: | Common genetic variation and the control of HIV-1 in humans |
Author: | Fellay, Jacques Ge, Dongliang Shianna, Kevin V. Colombo, Sara Ledergerber, Bruno Cirulli, Elisabeth T. Urban, Thomas J. Zhang, Kunlin Gumbs, Curtis E. Smith, Jason P. Castagna, Antonella Cozzi-Lepri, Alessandro De Luca, Andrea Easterbrook, Philippa Günthard, Huldrych F. Mallal, Simon Mussini, Cristina Dalmau, Judith Martínez Picado, Francisco Javier Miró Meda, José M. Obel, Niels Wolinsky, Steven Martinson, Jeremy J Detels, Roger Margolick, Joseph B. Jacobson, Lisa P. Descombes, Patrick Antonarakis, Stylianos E. Beckmann, Jacques O'Brien, Stephen J. Letvin, Norman L. McMichael, Andrew J. Haynes, Barton F. Carrington, Mary Feng, Sheng Telenti, Amalio Goldstein, David B. |
Keywords: | Genètica molecular VIH (Virus) Molecular genetics HIV (Viruses) |
Issue Date: | 24-Dec-2009 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pgen.1000791 |
It is part of: | PLoS Genetics, 2009, vol. 5, num. 12, p. e1000791. |
URI: | http://hdl.handle.net/2445/44169 |
Related resource: | http://dx.doi.org/10.1371/journal.pgen.1000791 |
ISSN: | 1553-7390 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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