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New strategies in the modulation of fatty acid oxidation as a treatment for obesity
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Strategies that enhance fat degradation or reduce caloric
food intake could be considered therapeutic interventions to reduce not
only obesity, but also its associated disorders. The enzyme carnitine
palmitoyltransferase 1 (CPT1) is the critical rate-determining regulator
of fatty acid oxidation (FAO) and might play a key role in increasing
energy expenditure and controlling food intake. Our group has shown
that mice overexpressing CPT1 in liver are protected from weight gain,
the development of obesity and insulin resistance. Regarding food
intake control, we observed that the pharmacological inhibition of
CPT1 in rat hypothalamus decreased food intake and body weight.
This suggests that modulation of CPT1 activity and the oxidation of
fatty acids in various tissues can be crucial for the potential treatment
of obesity and associated pathologies.
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HERRERO RODRÍGUEZ, Laura, MERA NANÍN, Paula, ORELLANA GAVALDÀ, Josep maria, GURUNATHAN, Chandrashekaran, MALANDRINO, Maria ida, MIR BONNÍN, Joan francesc, MAKOWSKI, Kamil, POZO, Macarena, ARASA, Maria del mar, ARIZA PIQUER, Xavier, ASINS MUÑOZ, Guillermina, GARCÍA GÓMEZ, Jordi, GARCÍA HEGARDT, Fausto, SERRA I CUCURULL, Dolors. New strategies in the modulation of fatty acid oxidation as a treatment for obesity. _Recent Advances in Pharmaceutical Sciences III_. 2013. Vol. Transworld Research Network : Editors: Diego Muñoz Torrero, núm. Mariño, pàgs. 77-89. [consulta: 11 de desembre de 2025]. [Disponible a: https://hdl.handle.net/2445/46996]