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http://hdl.handle.net/2445/55267| Title: | Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization |
| Author: | Hernández Romero, Delia Riego, Estela Francesch, Andrés Cuevas, Carmen Albericio Palomera, Fernando Álvarez Domingo, Mercedes |
| Keywords: | Productes naturals Pèptids Síntesi orgànica Compostos heterocíclics Natural products Peptides Organic synthesis Heterocyclic compounds |
| Issue Date: | 10-Jul-2007 |
| Publisher: | Elsevier B.V. |
| Abstract: | Herein is described the synthesis of several analogs of the natural product IB-01211 from concatenated azoles, via a biomimetic pathway based on cyclization-oxidation of serine containing peptides combined with the Hantzsch synthesis. The macrocyclization of rigid peptide compounds 1 and 2 to give IB-01211 and its epimer 12b was explored, and the results are compared here to those previously obtained for the macrocyclization of more flexible structures in the syntheses of YM-216391, telomestatin, and IB-01211. Lastly, the preliminary results of anti-tumor activity screening of the synthesized analogs are discussed. |
| Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.tet.2007.06.103 |
| It is part of: | Tetrahedron, 2007, vol. 63, num. 39, p. 9862-9870 |
| URI: | http://hdl.handle.net/2445/55267 |
| Related resource: | http://dx.doi.org/10.1016/j.tet.2007.06.103 |
| ISSN: | 0040-4020 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 555878.pdf | 179.9 kB | Adobe PDF | View/Open |
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