Please use this identifier to cite or link to this item:
Title: Type-1 cannabinoid receptor activity during Alzheimer's disease progression 
Author: Manuel, Iván
González de San Román, Estíbaliz
Giralt, M. Teresa
Ferrer, Isidro (Ferrer Abizanda)
Rodríguez Puertas, Rafael
Keywords: Malaltia d'Alzheimer
Proteïnes G
Fixació de proteïnes
Alzheimer's disease
G Proteins
Protein binding
Issue Date: 10-Oct-2014
Publisher: IOS Press
Abstract: The activity of CB1 cannabinoid receptors was studied in postmortem brain samples of Alzheimer's disease (AD) patients during clinical deterioration. CB1 activity was higher at earlier AD stages in limited hippocampal areas and internal layers of frontal cortex, but a decrease was observed at the advanced stages. The pattern of modification appears to indicate initial hyperactivity of the endocannabinoid system in brain areas that lack classical histopathological markers at earlier stages of AD, indicating an attempt to compensate for the initial synaptic impairment, which is then surpassed by disease progression. These results suggest that initial CB1 stimulation might have therapeutic relevance.
Note: Reproducció del document publicat a:
It is part of: Journal of Alzheimer's Disease, 2014, vol. 42, num. 3, p. 761-766
Related resource:
ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
647707.pdf63.78 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.