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http://hdl.handle.net/2445/8263
Title: | Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model. |
Author: | Costelli, Paola Carbó Carbó, Neus Tessitore, Luciana Bagby, Gregory J. López-Soriano, Francisco J. Argilés Huguet, Josep Ma. Baccino, Francesco M. |
Keywords: | Tumors Necrosi Músculs Tumor necrosis factor Skeletal muscle Protein turnover |
Issue Date: | 1993 |
Publisher: | American Society for Clinical Investigation |
Abstract: | Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved. |
Note: | Reproducció del document publicat a http://dx.doi.org/doi:10.1172/JCI116897 |
It is part of: | Journal of Clinical Investigation, 1993, vol. 92, núm. 6, p. 2783-2789. |
URI: | http://hdl.handle.net/2445/8263 |
ISSN: | 0021-9738 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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