Please use this identifier to cite or link to this item:
Title: Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.
Author: Costelli, Paola
Carbó Carbó, Neus
Tessitore, Luciana
Bagby, Gregory J.
López-Soriano, Francisco J.
Argilés Huguet, Josep Ma.
Baccino, Francesco M.
Keywords: Tumors
Tumor necrosis factor
Skeletal muscle
Protein turnover
Issue Date: 1993
Publisher: American Society for Clinical Investigation
Abstract: Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved.
Note: Reproducció del document publicat a
It is part of: Journal of Clinical Investigation, 1993, vol. 92, núm. 6, p. 2783-2789.
ISSN: 0021-9738
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Files in This Item:
File Description SizeFormat 
79740.pdf1.28 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.