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2015

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cc-by-nc-nd (c) Sociedad Española de Nefrología, 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/110123

Kidney transplant from a living monozygotic twin donor with no maintenance immunosuppression.

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Recurs relacionat

https://doi.org/10.1016/j.nefro.2015.06.006

Resum

From a theoretical point of view, an alloimmune response can not take place, still some type of standard immunosuppression is used in about 60% of patients receiving kidney grafts from their monozygotic twins. We aimed at assessing clinical response in patients receiving renal grafts from a living monozygotic twin donor when no immunosuppressive therapy is used. METHODS: This is a retrospective observational study of patients receiving kidney grafts from their monozygotic twins from 1969 to 2013. The following data were recorded: age, renal graft recipient's primary disease, renal function, renal survival and overall survival. Immunosuppressive therapy included a single intraoperative dose of methylprednisolone 500 mg and no maintenance immunosuppression. RESULTS: Five patients with kidney grafts from their monozygotic twins were dentified in our centre. Mean age at transplantation was 33 years (27-39). One-year overall survival and graft survival were 100%. Mean creatinine level was 0.96 ± 0.2 one year after transplantation, and 1.2 ± 0.37 mg/dl at most recent follow-up. Two patients died with a functional graft more than 15 years after kidney transplantation (causes were melanoma and cardiovascular event respectively). Follow-up was lost in a patient one year after transplantation. Two patients are alive with a functioning graft at 18 months and 42.5 years after transplantation respectively. CONCLUSION: Kidney transplantation from a living monozygotic twin is associated to outstanding clinical outcomes. Immunossuppresive therapy to suppress alloimmune response in probably unnecessary 11 zygosity has been confirmed.

Matèries

Trasplantament renal, Immunosupressió, Bessons

Matèries (anglès)

Kidney transplantation, Immunosuppression, Twins

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Articles publicats en revistes (Medicina)

Citació

SÁNCHEZ-ESCUREDO, Ana, et al. Kidney transplant from a living monozygotic twin donor with no maintenance immunosuppression. Nefrología. 2015. Vol. 35, num. 4, pags. 358-362. ISSN 0211-6995. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/110123

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