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Association of PIWIL4 genetic variants with germ cell maturation arrest in infertile Spanish men
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Dear Editor, The PIWI proteins (originally P-element-induced wimpy testis
in Drosophila) are predominantly present in the germ-line in diverse
organisms and are involved in the processing of a class of small RNAs
known as piRNAs (see Refs.1,2 for review). The human PIWI protein
family consists of four members: PIWIL1–4. Of these, PIWIL4 is known
to have essential roles in the first phases of spermatogenesis: its expression
is restricted to gonocytes and it is required for transposon silencing.3
The
lack of this gene in mice causes meiotic arrest in spermatogenesis.4
The
goal of our study was to evaluate the frequency of several PIWIL4 genetic
variants in our population to better define the relationship between
PIWIL4 single nucleotide polymorphisms (SNPs) and both defective
spermatogenesis and specific spermatogenic disorders...
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MUÑOZ MIRALLES, Xavier, et al. Association of PIWIL4 genetic variants with germ cell maturation arrest in infertile Spanish men. Asian Journal of Andrology. 2014. Vol. 16, num. 6, pags. 931-933. [consulted: 14 of October of 2026]. Available at: https://hdl.handle.net/2445/126290