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2010-05

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126428

Human papillomavirus is not associated with colorectal cancer in a large international study

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Recurs relacionat

https://doi.org/10.1007/s10552-010-9502-0

Resum

Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer. The GP5+/GP6+ PCR reverse line blot method was used for detection of 37 types of human papillomavirus (HPV) in DNA from paraffin-embedded or frozen tissues from patients with colorectal cancer (n = 279) and normal adjacent tissue (n = 30) in three different study populations, including samples from the United States (n = 73), Israel (n = 106) and Spain (n = 100). Additionally, SPF10 PCR was run on all samples (n = 279) and the Innogenetics INNO-LiPA assay was performed on a subset of samples (n = 15). All samples were negative for all types of HPV using both the GP5+/GP6+ PCR reverse line blot method and the SPF10 INNO-LiPA method. We conclude that HPV types associated with malignant transformation do not meaningfully contribute to adenocarcinoma of the colon.

Matèries

Papil·lomavirus, Càncer colorectal

Matèries (anglès)

Papillomaviruses, Colorectal cancer

Citació

Col·leccions

Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

GORNICK, Michele C., et al. Human papillomavirus is not associated with colorectal cancer in a large international study. Cancer Causes & Control. 2010. Vol. 21, num. 5, pags. 737-743. ISSN 0957-5243. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/126428

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