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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/160881
Bioelectronic recordings of cardiomyocytes with accumulation mode electrolyte gated organic field effect transistors
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Organic electronic materials offer an untapped potential for novel tools for low-invasive electrophysiological recording and stimulation devices. Such materials combine semiconducting properties with tailored surface chemistry, elastic mechanical properties and chemical stability in water. In this work, we investigate solution processed Electrolyte Gated Organic Field Effect Transistors (EGOFETs) based on a small molecule semiconductor. We demonstrate that EGOFETs based on a blend of soluble organic semiconductor 2,8-Difluoro-5,11-bis(triethylsilylethynyl)anthradithiophene (diF-TES-ADT) combined with an insulating polymer show excellent sensitivity and long-term recording under electrophysiological applications. Our devices can stably record the extracellular potential of human pluripotent stem cell derived cardiomyocyte cells (hPSCs-CMs) for several weeks. In addition, cytotoxicity tests of pharmaceutical drugs, such as Norepinephrine and Verapamil was achieved with excellent sensitivity. This work demonstrates that organic transistors based on organic blends are excellent bioelectronics transducer for extracellular electrical recording of excitable cells and tissues thus providing a valid alternative to electrochemical transistors.
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Versió postprint del document publicat a: https://doi.org/10.1016/j.bios.2019.111844
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KYNDIAH, Adrica, LEONARDI, Francesca, TARANTINO, Carolina, CRAMER, Tobias, MILLÁN SOLSONA, Rubén, GARRETA, Elena, MONTSERRAT, Núria, MAS TORRENT, Marta, GOMILA LLUCH, Gabriel. Bioelectronic recordings of cardiomyocytes with accumulation mode electrolyte gated organic field effect transistors. _Biosensors and Bioelectronics_. 2020. Vol. 150, núm. 111844. [consulta: 23 de gener de 2026]. ISSN: 0956-5663. [Disponible a: https://hdl.handle.net/2445/160881]