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12885_2023_Article_11056.pdf (1.38 MB)

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2023-06-19

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cc by (c) Christakoudi, Sofia et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/207967

A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

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https://doi.org/10.1186/s12885-023-11056-1

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Background Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI). Methods We evaluated body shape with the allometric a body shape index (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Results During a mean follow-up of 14.0 years, 9011 incident breast cancers were diagnosed among 218,276 women. Although there was little evidence for association of ABSI with breast cancer overall (hazard ratio HR = 0.984; 95% confidence interval: 0.961-1.007), we found borderline inverse associations for post-menopausal women (HR = 0.971; 0.942-1.000; n = 5268 cases) and breast cancers diagnosed at age >= 55 years (HR = 0.976; 0.951-1.002; n = 7043) and clear inverse associations for ER + PR- subtypes (HR = 0.894; 0.822-0.971; n = 726) and ER-PR- subtypes (HR = 0.906; 0.835-0.983 n = 759). There were no material associations with HI. BMI was associated strongly positively with breast cancer overall (HR = 1.074; 1.049-1.098), for post-menopausal women (HR = 1.117; 1.085-1.150), for cancers diagnosed at age >= 55 years (HR = 1.104; 1.076-1.132), and for ER + PR + subtypes (HR = 1.122; 1.080-1.165; n = 3101), but not for PR- subtypes. Conclusions In the EPIC cohort, abdominal obesity evaluated with ABSI was not associated with breast cancer risk overall but was associated inversely with the risk of post-menopausal PR- breast cancer. Our findings require validation in other cohorts and with a larger number of PR- breast cancer cases.

Matèries

Progesterona, Dones de mitjana edat

Matèries (anglès)

Progesterone, Middle-aged women

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

CHRISTAKOUDI, Sofia, TSILIDIS, Konstantinos k., DOSSUS, Laure, RINALDI, Sabina, WEIDERPASS, Elisabete, ANTONIUSSEN, Christian s., DAHM, Christina c., TJØNNELAND, Anne, MELLEMKJÆR, Lene, KATZKE, Verena, KAAKS, Rudolf, SCHULZE, Matthias b., MASALA, Giovanna, GRIONI, Sara, PANICO, Salvatore, TUMINO, Rosario, SACERDOTE, Carlotta, MAY, Anne m., MONNINKHOF, Evelyn m., QUIRÓS, José ramón, BONET, Catalina, SÁNCHEZ, Maria jose, AMIANO, Pilar, CHIRLAQUE, María dolores, GUEVARA, Marcela, ROSENDAHL, Ann h., STOCKS, Tanja, PEREZ-CORNAGO, Aurora, TIN TIN, Sandar, HEATH, Alicia k., AGLAGO, Elom k., PERUCHET NORAY, Laia, FREISLING, Heinz, RIBOLI, Elio. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort. _BMC Cancer_. 2023. Vol. 23, núm. 1. [consulta: 15 de gener de 2026]. ISSN: 1471-2407. [Disponible a: https://hdl.handle.net/2445/207967]

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