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cc by-nc-nd (c) Sequí Sabater, José Miguel et al, 2025
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/219027

Artificial intelligence in rheumatology research: what is it good for?

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Artificial intelligence (AI) is transforming rheumatology research, with a myriad of studies aiming to improve diagnosis, prognosis and treatment prediction, while also showing potential capability to optimise the research workflow, improve drug discovery and clinical trials. Machine learning, a key element of discriminative AI, has demonstrated the ability of accurately classifying rheumatic diseases and predicting therapeutic outcomes by using diverse data types, including structured databases, imaging and text. In parallel, generative AI, driven by large language models, is becoming a powerful tool for optimising the research workflow by supporting with content generation, literature review automation and clinical decision support. This review explores the current applications and future potential of both discriminative and generative AI in rheumatology. It also highlights the challenges posed by these technologies, such as ethical concerns and the need for rigorous validation and regulatory oversight. The integration of AI in rheumatology promises substantial advancements but requires a balanced approach to optimise benefits and minimise potential possible downsides.

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SEQUÍ SABATER, José Miguel and BENAVENT, Diego. Artificial intelligence in rheumatology research: what is it good for?. RMD Open. 2025. Vol. 11, num. 1. ISSN 2056-5933. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/219027

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