Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

dmm050079.pdf (781.2 KB)

Document type

Article

Version

Published version

Publication date

2023-06-06

Publication license

cc by (c) Cerón, Julián et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/202078

Caenorhabditis elegans for research on cancer hallmarks

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1242/dmm.050079

Abstract

After decades of research, our knowledge of the complexity of cancer mechanisms, elegantly summarized as 'hallmarks of cancer', is expanding, as are the therapeutic opportunities that this knowledge brings. However, cancer still needs intense research to diminish its tremendous impact. In this context, the use of simple model organisms such as Caenorhabditis elegans, in which the genetics of the apoptotic pathway was discovered, can facilitate the investigation of several cancer hallmarks. Amenable for genetic and drug screens, convenient for fast and efficient genome editing, and aligned with the 3Rs ('Replacement, Reduction and Refinement') principles for ethical animal research, C . elegans plays a significant role in unravelling the intricate network of cancer mechanisms and presents a promising option in clinical diagnosis and drug discovery.

Subject

Genètica del desenvolupament, Càncer

Subject (English)

Developmental genetics, Cancer

Citation

Collections

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

CERÓN MADRIGAL, Julián. Caenorhabditis elegans for research on cancer hallmarks. Disease Models & Mechanisms. 2023. Vol. 16, num. 6. ISSN 1754-8411. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/202078

Export metadata

JSON - METS

Share record