Dijous 11 de juny, el Dipòsit Digital no estarà operatiu de 15:00 a 17:00 h per tasques de manteniment. Disculpeu les molèsties.
El jueves 11 de Junio, el Dipòsit Digital no estará operativo de 15:00 a 17:00 h debido a tareas de mantenimiento. Disculpen las molestias.
Thursday, Jun 11th, the Digital Repository will be unavailable due to a system update.

Files

645555.pdf (1.05 MB)

Document type

Article

Version

Published version

Publication date

2014-10-28

Publication license

cc-by (c) Merino Montero, Susana et al., 2014
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/61173

Role of Aeromonas hydrophila flagella glycosylation in adhesion to Hep-2 cells, biofilm formation and immune stimulation.

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

http://dx.doi.org/10.3390/ijms151221935

Abstract

Polar flagellin proteins from Aeromonas hydrophila strain AH-3 (serotype O34) were found to be O-glycosylated with a heterogeneous heptasaccharide glycan. Two mutants with altered (light and strong) polar flagella glycosylation still able to produce flagella were previously obtained, as well as mutants lacking the O34-antigen lipopolysaccharide (LPS) but with unaltered polar flagella glycosylation. We compared these mutants, altogether with the wild type strain, in different studies to conclude that polar flagella glycosylation is extremely important for A. hydrophila adhesion to Hep-2 cells and biofilm formation. Furthermore, the polar flagella glycosylation is an important factor for the immune stimulation of IL-8 production via toll receptor 5 (TLR5).

Subject

Bacteris, Flagel·lats, Regulació genètica, Autoimmunitat

Subject (English)

Bacteria, Flagellata, Genetic regulation, Autoimmunity

Citation

Collections

Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citation

MERINO MONTERO, Susana, WILHELMS, Markus and TOMÀS MAGAÑA, Juan. Role of Aeromonas hydrophila flagella glycosylation in adhesion to Hep-2 cells, biofilm formation and immune stimulation. International Journal of Molecular Sciences. 2014. Vol. 15, num. 21935-21946. ISSN 1422-0067. [consulted: 11 of June of 2026]. Available at: https://hdl.handle.net/2445/61173

Export metadata

JSON - METS

Share record