Role of Aeromonas hydrophila flagella glycosylation in adhesion to Hep-2 cells, biofilm formation and immune stimulation.

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dc.contributor.authorMerino Montero, Susana
dc.contributor.authorWilhelms, Markus
dc.contributor.authorTomàs Magaña, Juan
dc.date.accessioned2015-01-12T15:34:44Z
dc.date.available2015-01-12T15:34:44Z
dc.date.issued2014-10-28
dc.date.updated2015-01-12T15:34:44Z
dc.description.abstractPolar flagellin proteins from Aeromonas hydrophila strain AH-3 (serotype O34) were found to be O-glycosylated with a heterogeneous heptasaccharide glycan. Two mutants with altered (light and strong) polar flagella glycosylation still able to produce flagella were previously obtained, as well as mutants lacking the O34-antigen lipopolysaccharide (LPS) but with unaltered polar flagella glycosylation. We compared these mutants, altogether with the wild type strain, in different studies to conclude that polar flagella glycosylation is extremely important for A. hydrophila adhesion to Hep-2 cells and biofilm formation. Furthermore, the polar flagella glycosylation is an important factor for the immune stimulation of IL-8 production via toll receptor 5 (TLR5).
dc.format.extent12 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec645555
dc.identifier.issn1422-0067
dc.identifier.pmid25464381
dc.identifier.urihttps://hdl.handle.net/2445/61173
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.3390/ijms151221935
dc.relation.ispartofInternational Journal of Molecular Sciences, 2014, vol. 15, p. 21935-21946
dc.relation.urihttp://dx.doi.org/10.3390/ijms151221935
dc.rightscc-by (c) Merino Montero, Susana et al., 2014
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Genètica, Microbiologia i Estadística)
dc.subject.classificationBacteris
dc.subject.classificationFlagel·lats
dc.subject.classificationRegulació genètica
dc.subject.classificationAutoimmunitat
dc.subject.otherBacteria
dc.subject.otherFlagellata
dc.subject.otherGenetic regulation
dc.subject.otherAutoimmunity
dc.titleRole of Aeromonas hydrophila flagella glycosylation in adhesion to Hep-2 cells, biofilm formation and immune stimulation.
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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