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2018-08-25

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cc-by-nc-nd (c) Ambrosioni, Juan et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/184345

HACEK infective endocarditis: epidemiology, clinical features outcome: A case-control study

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https://doi.org/10.1016/j.ijid.2018.08.013

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OBJECTIVES: The study aimed to describe the epidemiology, microbiological and clinical features of a population sample of 17 patients with HACEK-IE and to compare them with matched control patients with IE caused by Viridans group Streptococci (VGS-IE). METHODS: Description of definite (14; 82.2%) and possible (3; 17.6%) HACEK-IE included in the 'Infective Endocarditis Hospital Clínic of Barcelona' (IE-HCB) database between 1979 and 2016. Furthermore, a retrospective case-control analysis was performed, matching each case to three VGS-IE controls registered in the same database during the same period of time. RESULTS: Seventeen out of 1,209 IE cases (1.3%, 95%CI 0.69-1.91) were due to HACEK group. The most frequent isolated HACEK species were Aggregatibacter spp (11; 64.7%). Intracardiac vegetations were present in 70.6% of cases. Left heart failure (LHF) was present in 29.4% of cases. Ten patients (58.8%) required in-hospital surgery and none died during hospitalization. In the case-control analysis, there was a trend toward larger vegetations in the HACEK-IE group (median (IRQ) size=11.5 (10.0-20.0) mm vs 9.0 (7.0-13.0) mm; p=0.068). Clinical manifestations, echocardiographic findings, LHF rate, systemic emboli and other complications were all comparable (p >0.05). In-hospital surgery and mortality were similar for both groups. One-year mortality was lower for HACEK-IE (1/17 vs. to 6/48, p=0.006). CONCLUSIONS: HACEK-IE represented 1.3% of all IE cases. Clinical features and outcome were comparable with the VGS-IE control group. Despite the trend tow

Matèries

Endocarditis, Epidemiologia, Medicina clínica

Matèries (anglès)

Endocarditis, Epidemiology, Clinical medicine

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

Citació

AMBROSIONI, Juan, MARTÍNEZ GARCÍA, Clara, LLOPIS, Jaume, GARCÍA DE LA MÀRIA, Cristina, HERNÁNDEZ-MENESES, Marta, TELLEZ, Adrian, FALCES SALVADOR, Carles, ALMELA, Manel, VIDAL, Bàrbara, SANDOVAL, Elena, FUSTER, David, QUINTANA, Eduard, TOLOSANA, José m. (josé maría), MARCO, Francesc, MORENO, Asunción, MIRÓ MEDA, José m. (josé maría), The Hospital Clinic Infective Endocarditis Investigators. HACEK infective endocarditis: epidemiology, clinical features outcome: A case-control study. _International Journal of Infectious Diseases_. 2018. Vol. 76, núm. 120-125. [consulta: 24 de gener de 2026]. ISSN: 1201-9712. [Disponible a: https://hdl.handle.net/2445/184345]

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