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23969873251367250.pdf (647.84 KB)

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2025-09-03

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cc-by (c) Lázaro, Iolanda et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/228784

Development of a blood-based lipidomic fat quality score for the risk of ischemic stroke

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Recurs relacionat

https://doi.org/10.1093/esj/23969873251367250

Resum

Introduction: Poor-quality diets promote ischemic stroke. Red blood cell fatty acids (RBC-FAs) are objective, longterm biomarkers of diet. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain, we developed a blood-based lipidomic fat quality (LFQ) score considering pre-defined RBC-FA diet-related biomarkers, and examined whether LFQ score relates to the risk of ischemic stroke. Patients and methods: We determined the RBC-FAs (n = 438 cases of incident ischemic stroke, n= 438 matched controls). For each participant, we scored 1 for each beneficial metric (C15:0+C17:0; C18:2n-6; C18:3n-3; C20:5n-3; C22:6n-3) >= the median of the control group; and 1 for each detrimental metric (C16:0; C16:1n-7; C18:0) < the median of the control group. LFQ score resulted from the 8-component sum (range = 0-8; higher values, higher fat quality). We explored the validity of findings in a different background (n = 2468 participants from the Framingham Offspring Study without ischemic stroke at baseline, 12-year median follow-up, n= 121 cases). Results: In a fully adjusted model, the Odds Ratio (OR) for ischemic stroke was 0.86 (95% confidence interval [CI] = 0.77-0.95) for each 1-unit increase of the LFQ score. Compared to individuals at the lowest category of LFQ score (0-3 points), those at the top category (5-8 points) had lower odds (OR = 0.64, 95% CI = 0.44-0.94). The findings were similar in the Framingham Offspring Study (Hazard Ratio [HR] for each 1-unit increase = 0.83; 95% CI = 0.70-0.99; HR for those at top category = 0.49; 95% CI = 0.29-0.84, compared to those at the lowest category). Conclusion: Low blood-based LFQ scores relate to a high risk of ischemic stroke.

Matèries

Àcids grassos en la nutrició, Metabolisme dels lípids, Malalties cerebrovasculars

Matèries (anglès)

Fatty acids in human nutrition, Lipid metabolism, Cerebrovascular disease

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

LÁZARO, Iolanda, et al. Development of a blood-based lipidomic fat quality score for the risk of ischemic stroke. European Stroke Journal. 2026. Vol. 11, num. 1. ISSN 2396-9881. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/228784

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